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1 Neuromuscular Research Center, Department of Biology of Physical Activity, 4 Department of Health Sciences, University of Jyväskylä, 40351 Jyväskylä, 3 LIKES Research Center for Sport and Health Sciences, 40700 Jyväskylä, 5 Department of Sports Medicine, Deaconess Institute of Oulu, 90100 Oulu, Finland; 2 Sports Medicine Research Unit, Bispebjerg Hospital, 2400 Copenhagen NV, and Copenhagen Muscle Research Centre, Rigshospitalet, 2100 Copenhagen Ø, Denmark
This experiment
tested the hypothesis that running-induced damage to rat skeletal
muscle causes changes in synthesis and degradation of basement membrane
type IV collagen and to proteins regulating its degradation. Samples
from soleus muscle and red and white parts of quadriceps femoris muscle
(MQF) were collected 6 h or 1, 2, 4, or 7 days after downhill
running. Increased muscle 
-glucuronidase activity indicated greater
muscle damage in the red part of MQF than in the white part of
MQF or soleus. In the red part of MQF, type IV collagen expression was
upregulated at the pretranslational level and the protein concentration
decreased, whereas matrix metalloproteinase-2 (MMP-2), a protein that
degrades type IV collagen, and tissue inhibitor of metalloproteinase-2
(TIMP-2), a protein that inhibits degradation, were increased in
parallel both at mRNA and protein levels. Type IV collagen mRNA level
increased in the white part of MQF and soleus muscle. The protein
concentration increased in the white part of MQF and was unchanged in
soleus muscle. MMP-2 and TIMP-2 changed only slightly in the white part of MQF and soleus muscle. The changes seem to depend on the severity of
myofiber injury and thus probably reflect reorganization of basement
membrane compounds.
matrix metalloproteinase; tissue inhibitor of metalloproteinase; damage; collagen degradation
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