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Am J Physiol Regul Integr Comp Physiol 280: R1301-R1307, 2001;
0363-6119/01 $5.00
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Vol. 280, Issue 5, R1301-R1307, May 2001

Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake

Juliana Irani Fratucci De Gobbi1, Laurival Antonio De Luca Jr.1, Alan Kim Johnson2, and José Vanderlei Menani1

1 Department of Physiology and Pathology, School of Dentistry, Paulista State University (UNESP), 14801 - 903 Araraquara, São Paulo, Brazil; and 2 Departments of Psychology and Pharmacology and Exercise Science and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242 - 1407

Serotonin [5-hydroxytryptamine (5-HT)] and CCK injected into the lateral parabrachial nucleus (LPBN) inhibit NaCl and water intake. In this study, we investigated interactions between 5-HT and CCK into the LPBN to control water and NaCl intake. Male Holtzman rats with cannulas implanted bilaterally in the LPBN were treated with furosemide + captopril to induce water and NaCl intake. Bilateral LPBN injections of high doses of the 5-HT antagonist methysergide (4 µg) or the CCK antagonist proglumide (50 µg), alone or combined, produced similar increases in water and 1.8% NaCl intake. Low doses of methysergide (0.5 µg) + proglumide (20 µg) produced greater increases in NaCl intake than when they were injected alone. The 5-HT2a/2c agonist 2,5-dimetoxy-4-iodoamphetamine hydrobromide (DOI; 5 µg) into the LPBN reduced water and NaCl intake. After proglumide (50 µg) + DOI treatment, the intake was not different from vehicle treatment. CCK-8 (1 µg) alone produced no effect. CCK-8 combined with methysergide (4 µg) reduced the effect of methysergide on NaCl intake. The data suggest that functional interactions between 5-HT and CCK in the LPBN may be important for exerting inhibitory control of NaCl intake.

5-hydroxytryptamine; proglumide; methysergide; NaCl intake; sodium appetite; angiotensin II


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