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Am J Physiol Regul Integr Comp Physiol 280: R1382-R1387, 2001;
0363-6119/01 $5.00
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Vol. 280, Issue 5, R1382-R1387, May 2001

Intestinal satiety protein apolipoprotein AIV is synthesized and regulated in rat hypothalamus

Min Liu1, Takashi Doi1, Ling Shen1, Stephen C. Woods2, Randy J. Seeley2, Shuqin Zheng1, Alana Jackman2, and Patrick Tso1

1 Department of Pathology and Laboratory Medicine and 2 Department of Psychiatry, University of Cincinnati School of Medicine, Cincinnati, Ohio 45267

Apolipoprotein AIV (apo AIV) is a satiety protein secreted by the small intestine. We demonstrate for the first time that apo AIV protein and apo AIV mRNA are present in rat hypothalamus, a site intimately involved in the integration of signals for regulation of food intake and energy metabolism. We further characterized the regulation of hypothalamic apo AIV mRNA levels. Food-deprived animals showed a pronounced decrease in gene expression of apo AIV in the hypothalamus, with a concomitant decrease in the jejunum. Refeeding fasted rats with standard laboratory chow for 4 h evokes a significant increase of apo AIV mRNA in jejunum but not in hypothalamus. However, lipid refeeding to the fasted animals restored apo AIV mRNA levels both in hypothalamus and jejunum. Intracerebroventricular administration of apo AIV antiserum not only stimulated feeding, but also decreased apo AIV mRNA level in the hypothalamus. These data further confirm the central role of apo AIV in the regulation of food intake.

satiety factor; competitive reverse transcription polymerase chain reaction; food intake; central nervous system


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