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Department of Physiology and Biophysics, Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, Mississippi 39216
The
purpose of this study was to determine the role of endothelin in
mediating the renal hemodynamic and arterial pressure changes observed
during chronic ANG II-induced hypertension. ANG II (50 ng · kg
1 · min1) was
chronically infused into the jugular vein by miniosmotic pump for 2 wk
in male Sprague-Dawley rats with and without endothelin type A
(ETA)-receptor antagonist ABT-627 (5 mg · kg1 · day1)
pretreatment. Arterial pressure increased in ANG II rats compared with
control rats (149 ± 5 vs. 121 ± 6 mmHg, P < 0.05, respectively). Renal expression of preproendothelin mRNA was
increased by ~50% in both the medulla and cortex of ANG II rats. The
hypertensive effect of ANG II was completely abolished in rats
pretreated with the ETA-receptor antagonist (114 ± 5 mmHg, P < 0.05). Glomerular filtration rate was
decreased by 33% in ANG II rats, and this response was attenuated in
rats pretreated with ETA-receptor antagonist. These data
indicate that activation of the renal endothelin system by ANG II may
play an important role in mediating chronic renal and hypertensive
actions of ANG II.
glomerular filtration rate; mean arterial pressure; renal preproendothelin
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