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Am J Physiol Regul Integr Comp Physiol 280: R1414-R1419, 2001;
0363-6119/01 $5.00
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Vol. 280, Issue 5, R1414-R1419, May 2001

Role of spinal alpha 1-adrenoceptor subtypes in the bladder reflex in anesthetized rats

Mitsuharu Yoshiyama1,2,3 and William C. De Groat1

1 Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 15261; 2 Department of Neurology, Chiba University Graduate School of Medicine, Chiba, 260 - 8670; and 3 Department of Neurology, Chiba-Higashi National Hospital, Chiba, 260 - 8712, Japan

The contribution of different subtypes of alpha 1-adrenoceptors in the lumbosacral spinal cord to the control of the urinary bladder was examined in urethane-anesthetized rats. Bladder pressure was recorded via a transurethral catheter under isovolumetric conditions. Drugs were administered intrathecally at the L6-S1 segmental level of spinal cord. RS-100329 (an alpha 1A-antagonist) in doses of 25, 50, and 100 nmol significantly decreased bladder-contraction amplitude by 38%, 52%, and 95%, respectively, whereas (+)-cyclazosin (an alpha 1B-antagonist) significantly decreased bladder-contraction amplitude (48% reduction) only in a 50-nmol but not a 100-nmol dose. Fifty nanomoles of RS-100329 and (+)-cyclazosin increased bladder-contraction frequency by 54% and 44%, respectively. BMY7378 (an alpha 1D-antagonist), in doses of 25, 50, and 100 nmol, did not change bladder activity. These studies suggest that reflex-bladder activity is modulated by two types of spinal alpha 1-adrenergic mechanisms: 1) alpha 1A- or alpha 1B-inhibitory control of the frequency of voiding reflexes presumably mediated by an alteration in the processing of bladder afferent input and 2) alpha 1A-facilitatory modulation of the descending efferent limb of the micturition-reflex pathway. Spinal alpha 1D-adrenoceptors do not appear to have a significant role at either site.

afferents; descending efferents; locus ceruleus


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