AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 280: R1483-R1487, 2001;
0363-6119/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (111)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nagaya, N.
Right arrow Articles by Kangawa, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nagaya, N.
Right arrow Articles by Kangawa, K.
Vol. 280, Issue 5, R1483-R1487, May 2001

Hemodynamic and hormonal effects of human ghrelin in healthy volunteers

Noritoshi Nagaya1, Masayasu Kojima2, Masaaki Uematsu3, Masakazu Yamagishi1, Hiroshi Hosoda2, Hideo Oya1, Yujiro Hayashi4, and Kenji Kangawa2

Departments of 1 Internal Medicine and 2 Biochemistry, National Cardiovascular Center, Osaka 565 - 8565; 3 Department of Internal Medicine, Osaka Seamen's Insurance Hospital, Osaka 552-0021; and 4 Institute for Medical Research and Development, Suntory Limited, Gunma 370-0503, Japan

To investigate hemodynamic and hormonal effects of ghrelin, a novel growth hormone (GH)-releasing peptide, we gave six healthy men an intravenous bolus of human ghrelin (10 µg/kg) or placebo and vice versa 1-2 wk apart in a randomized fashion. Ghrelin elicited a marked increase in circulating GH (15-fold). The elevation of GH lasted longer than 60 min after the bolus injection. Injection of ghrelin significantly decreased mean arterial pressure (-12 mmHg, P < 0.05) without a significant change in heart rate (-4 beats/min, P = 0.39). Ghrelin significantly increased cardiac index (+16%, P < 0.05) and stroke volume index (+22%, P < 0.05). We also examined ghrelin receptor [GH secretagogues receptor (GHS-R)] gene expression in the aortas, the left ventricles, and the left atria of rats by RT-PCR. GHS-R mRNA was detectable in the rat aortas, left ventricles, and left atria, suggesting that ghrelin may cause cardiovascular effects through GH-independent mechanisms. In summary, human ghrelin elicited a potent, long-lasting GH release and had beneficial hemodynamic effects via reducing cardiac afterload and increasing cardiac output without an increase in heart rate.

hemodynamics; hormones; vasodilation


This article has been cited by other articles:


Home page
 J Clin PharmacolHome page
K. C. Lasseter, L. Shaughnessy, D. Cummings, J. C. Pezzullo, W. Wargin, R. Gagnon, J. Oliva, and G. Kosutic
Ghrelin Agonist (TZP-101): Safety, Pharmacokinetics and Pharmacodynamic Evaluation in Healthy Volunteers: A Phase I, First-in-Human Study
J. Clin. Pharmacol., February 1, 2008; 48(2): 193 - 202.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. T. Vestergaard, N. H. Andersen, T. K. Hansen, L. M. Rasmussen, N. Moller, K. E. Sorensen, E. Sloth, and J. O. L. Jorgensen
Cardiovascular effects of intravenous ghrelin infusion in healthy young men
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3020 - H3026.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
J.-N. Ma, H. H. Schiffer, A. E. Knapp, J. Wang, K. K. Wong, E. A. Currier, M. Owens, N. R. Nash, L. R. Gardell, M. R. Brann, et al.
Identification of the Atypical L-Type Ca2+ Channel Blocker Diltiazem and Its Metabolites As Ghrelin Receptor Agonists
Mol. Pharmacol., August 1, 2007; 72(2): 380 - 386.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
N. Tawadros, L.A. Salamonsen, E. Dimitriadis, and C. Chen
Facilitation of decidualization by locally produced ghrelin in the human endometrium
Mol. Hum. Reprod., July 1, 2007; 13(7): 483 - 489.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
A. Arepally, B. P. Barnett, E. Montgomery, and T. H. Patel
Catheter-directed Gastric Artery Chemical Embolization for Modulation of Systemic Ghrelin Levels in a Porcine Model: Initial Experience
Radiology, July 1, 2007; 244(1): 138 - 143.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. T. Vestergaard, T. K. Hansen, L. C. Gormsen, P. Jakobsen, N. Moller, J. S. Christiansen, and J. O. L. Jorgensen
Constant intravenous ghrelin infusion in healthy young men: clinical pharmacokinetics and metabolic effects
Am J Physiol Endocrinol Metab, June 1, 2007; 292(6): E1829 - E1836.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
A. Baessler, M. Fischer, B. Mayer, M. Koehler, S. Wiedmann, K. Stark, A. Doering, J. Erdmann, G. Riegger, H. Schunkert, et al.
Epistatic interaction between haplotypes of the ghrelin ligand and receptor genes influence susceptibility to myocardial infarction and coronary artery disease
Hum. Mol. Genet., April 15, 2007; 16(8): 887 - 899.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Iantorno, H. Chen, J.-a Kim, M. Tesauro, D. Lauro, C. Cardillo, and M. J. Quon
Ghrelin has novel vascular actions that mimic PI 3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells
Am J Physiol Endocrinol Metab, March 1, 2007; 292(3): E756 - E764.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
R. R. Kraemer and V. D. Castracane
Exercise and Humoral Mediators of Peripheral Energy Balance: Ghrelin and Adiponectin
Experimental Biology and Medicine, February 1, 2007; 232(2): 184 - 194.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
A. E. Wertz-Lutz, T. J. Knight, R. H. Pritchard, J. A. Daniel, J. A. Clapper, A. J. Smart, A. Trenkle, and D. C. Beitz
Circulating ghrelin concentrations fluctuate relative to nutritional status and influence feeding behavior in cattle
J Anim Sci, December 1, 2006; 84(12): 3285 - 3300.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
J Tack, I Depoortere, R Bisschops, C Delporte, B Coulie, A Meulemans, J Janssens, and T Peeters
Influence of ghrelin on interdigestive gastrointestinal motility in humans
Gut, March 1, 2006; 55(3): 327 - 333.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. J. Kleinz, J. J. Maguire, J. N. Skepper, and A. P. Davenport
Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man
Cardiovasc Res, January 1, 2006; 69(1): 227 - 235.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
A. P. Davenport, T. I. Bonner, S. M. Foord, A. J. Harmar, R. R. Neubig, J.-P. Pin, M. Spedding, M. Kojima, and K. Kangawa
International Union of Pharmacology. LVI. Ghrelin Receptor Nomenclature, Distribution, and Function
Pharmacol. Rev., December 1, 2005; 57(4): 541 - 546.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
C D R Murray, N M Martin, M Patterson, S A Taylor, M A Ghatei, M A Kamm, C Johnston, S R Bloom, and A V Emmanuel
Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study
Gut, December 1, 2005; 54(12): 1693 - 1698.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
R. Wu, W. Dong, M. Zhou, X. Cui, H. Hank Simms, and P. Wang
Ghrelin improves tissue perfusion in severe sepsis via downregulation of endothelin-1
Cardiovasc Res, November 1, 2005; 68(2): 318 - 326.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
X.-B. Xu, J.-J. Pang, J.-M. Cao, C. Ni, R.-K. Xu, X.-Z. Peng, X.-X. Yu, S. Guo, M.-C. Chen, and C. Chen
GH-releasing peptides improve cardiac dysfunction and cachexia and suppress stress-related hormones and cardiomyocyte apoptosis in rats with heart failure
Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1643 - H1651.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
G. P. Zaloga
Ghrelin, Diet, and Pulmonary Function
Chest, September 1, 2005; 128(3): 1084 - 1086.
[Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
K. Wynne, K. Giannitsopoulou, C. J. Small, M. Patterson, G. Frost, M. A. Ghatei, E. A. Brown, S. R. Bloom, and P. Choi
Subcutaneous Ghrelin Enhances Acute Food Intake in Malnourished Patients Who Receive Maintenance Peritoneal Dialysis: A Randomized, Placebo-Controlled Trial
J. Am. Soc. Nephrol., July 1, 2005; 16(7): 2111 - 2118.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. Kojima and K. Kangawa
Ghrelin: Structure and Function
Physiol Rev, April 1, 2005; 85(2): 495 - 522.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
N. Nagaya, J. Moriya, Y. Yasumura, M. Uematsu, F. Ono, W. Shimizu, K. Ueno, M. Kitakaze, K. Miyatake, and K. Kangawa
Effects of Ghrelin Administration on Left Ventricular Function, Exercise Capacity, and Muscle Wasting in Patients With Chronic Heart Failure
Circulation, December 14, 2004; 110(24): 3674 - 3679.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. Henriques-Coelho, J. Correia-Pinto, R. Roncon-Albuquerque Jr, M. J. Baptista, A. P. Lourenco, S. M. Oliveira, A. Brandao-Nogueira, A. Teles, J. M. Fortunato, and A. F. Leite-Moreira
Endogenous production of ghrelin and beneficial effects of its exogenous administration in monocrotaline-induced pulmonary hypertension
Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2885 - H2890.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. J. Pemberton, H. Tokola, Z. Bagi, A. Koller, J. Pontinen, A. Ola, O. Vuolteenaho, I. Szokodi, and H. Ruskoaho
Ghrelin induces vasoconstriction in the rat coronary vasculature without altering cardiac peptide secretion
Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1522 - H1529.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. Wu, M. Zhou, X. Cui, H. H. Simms, and P. Wang
Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis
Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1296 - H1302.
[Abstract] [Full Text] [PDF]

Home page
 Arch SurgHome page
E. Lin, N. Gletsu, K. Fugate, D. McClusky, L. H. Gu, J.-L. Zhu, B. J. Ramshaw, D. A. Papanicolaou, T. R. Ziegler, and C. D. Smith
The Effects of Gastric Surgery on Systemic Ghrelin Levels in the Morbidly Obese
Arch Surg, July 1, 2004; 139(7): 780 - 784.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
B. E. Salfen, J. A. Carroll, D. H. Keisler, and T. A. Strauch
Effects of exogenous ghrelin on feed intake, weight gain, behavior, and endocrine responses in weanling pigs
J Anim Sci, July 1, 2004; 82(7): 1957 - 1966.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
A. J. van der Lely, M. Tschop, M. L. Heiman, and E. Ghigo
Biological, Physiological, Pathophysiological, and Pharmacological Aspects of Ghrelin
Endocr. Rev., June 1, 2004; 25(3): 426 - 457.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. J Iglesias, R. Pineiro, M. Blanco, R. Gallego, C. Dieguez, O. Gualillo, J. R Gonzalez-Juanatey, and F. Lago
Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes
Cardiovasc Res, June 1, 2004; 62(3): 481 - 488.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J.-J. Pang, R.-K. Xu, X.-B. Xu, J.-M. Cao, C. Ni, W.-L. Zhu, K. Asotra, M.-C. Chen, and C. Chen
Hexarelin protects rat cardiomyocytes from angiotensin II-induced apoptosis in vitro
Am J Physiol Heart Circ Physiol, March 1, 2004; 286(3): H1063 - H1069.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. M. Poykko, E. Kellokoski, S. Horkko, H. Kauma, Y. A. Kesaniemi, and O. Ukkola
Low Plasma Ghrelin Is Associated With Insulin Resistance, Hypertension, and the Prevalence of Type 2 Diabetes
Diabetes, October 1, 2003; 52(10): 2546 - 2553.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
W. A. Cupples
Peptides that regulate food intake
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1370 - R1374.
[Full Text] [PDF]

Home page
 Arch SurgHome page
D. E. Cummings and M. H. Shannon
Roles for Ghrelin in the Regulation of Appetite and Body Weight
Arch Surg, April 1, 2003; 138(4): 389 - 396.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. J. Kuo, O. B. Jones, and J. E. Hall
Chronic cardiovascular and renal actions of leptin during hyperinsulinemia
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R1037 - R1042.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
G. Baldanzi, N. Filigheddu, S. Cutrupi, F. Catapano, S. Bonissoni, A. Fubini, D. Malan, G. Baj, R. Granata, F. Broglio, et al.
Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT
J. Cell Biol., December 23, 2002; 159(6): 1029 - 1037.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M.L. Barreiro, F. Gaytan, J.E. Caminos, L. Pinilla, F.F. Casanueva, E. Aguilar, C. Dieguez, and M. Tena-Sempere
Cellular Location and Hormonal Regulation of Ghrelin Expression in Rat Testis
Biol Reprod, December 1, 2002; 67(6): 1768 - 1776.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
P. Lucidi, G. Murdolo, C. Di Loreto, A. De Cicco, N. Parlanti, C. Fanelli, F. Santeusanio, G. B. Bolli, and P. De Feo
Ghrelin Is Not Necessary for Adequate Hormonal Counterregulation of Insulin-Induced Hypoglycemia
Diabetes, October 1, 2002; 51(10): 2911 - 2914.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
N. Nagaya, M. Uematsu, M. Kojima, Y. Date, M. Nakazato, H. Okumura, H. Hosoda, W. Shimizu, M. Yamagishi, H. Oya, et al.
Elevated Circulating Level of Ghrelin in Cachexia Associated With Chronic Heart Failure: Relationships Between Ghrelin and Anabolic/Catabolic Factors
Circulation, October 23, 2001; 104(17): 2034 - 2038.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online