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Am J Physiol Regul Integr Comp Physiol 280: R1865-R1869, 2001;
0363-6119/01 $5.00
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Vol. 280, Issue 6, R1865-R1869, June 2001

Transplantation of rat metanephroi into mice

Sharon A. Rogers and Marc R. Hammerman

George M. O'Brien Kidney and Urological Disease Center, Renal Division, Departments of Medicine, Cell Biology, and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110

To determine whether transplanted metanephroi grow and differentiate after implantation into the omentum in hosts of a different species, we implanted metanephroi from embryonic day 15 (E15) rat embryos into uninephrectomized mice (hosts). Some host mice received human CTLA4Ig (hCTLA4Ig), anti-CD45RB, and anti-CD154 (tolerance-inducing agents). E15 metanephroi contained only metanephric blastema, segments of ureteric bud, and primitive nephrons with no glomeruli. Rat metanephroi did not grow or differentiate in mice that received no tolerance-inducing agents. However, by 2 wk posttransplantation in mice that received hCTLA4Ig, anti-CD45RB, and anti-CD154, metanephroi from E15 rats had enlarged, become vascularized, and formed mature tubules and glomeruli. Rat metanephroi contained cells that stained specifically for mouse CD31, a marker for sprouting endothelial cells. Some rat glomerular capillary loops stained positively for mouse CD31. Here, we show that chimeric kidneys develop from metanephroi transplanted ratright-arrowmouse and that glomeruli are vascularized, at least in part, by host vessels.

anti-CD31; anti-CD45RB; anti-CD154; CTLA4Ig; xenotransplantation


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