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Am J Physiol Regul Integr Comp Physiol 281: R150-R154, 2001;
0363-6119/01 $5.00
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Vol. 281, Issue 1, R150-R154, July 2001

Role of ETA receptors in experimental ANG II-induced hypertension in rats

Jennifer R. Ballew and Gregory D. Fink

Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824

The objectives were to determine if ANG II-induced hypertension is maintained by activation of endothelin type A (ETA) receptors by endogenous ET-1 and if this effect is influenced by salt intake. Male rats were maintained on high sodium intake (HS; 6 meq/day) or on normal sodium intake (NS; 2 meq/day). Hypertension was produced by intravenous infusion of ANG II (5 ng/min) for 15 days. Five-day oral dosing with the selective ETA-receptor antagonist ABT-627 (~2 mg · kg-1 · day-1) reduced mean arterial pressure (MAP) to baseline levels in rats on HS receiving ANG II infusion, but it did not affect MAP in normotensive HS controls. In rats on NS, ABT-627 only transiently decreased MAP in rats receiving ANG II and slightly reduced MAP in normotensive controls. ABT-627 produced mild retention of sodium and water in NS rats receiving ANG II, but not in any other group. These results indicate that ET-1 plays a role in ANG II-induced hypertension via activation of ETA receptors and that this role is more prominent in rats on HS.

endothelin; blood pressure; salt


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