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Am J Physiol Regul Integr Comp Physiol 281: R547-R552, 2001;
0363-6119/01 $5.00
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Vol. 281, Issue 2, R547-R552, August 2001

Cardiovascular and renal responses to a high-fat diet in Osborne-Mendel rats

Sharyn M. Fitzgerald1, Jeffrey R. Henegar2, Michael W. Brands2, Lisa K. Henegar1, and John E. Hall2

Departments of 1 Physiology and Biophysics and 2 Pathology, University of Mississippi Medical Center, Jackson, Mississippi 39216 - 4505

This study examined the cardiovascular, renal, and hormonal responses of dietary-induced obesity in Osborne-Mendel (OM) rats. Male OM rats were fed either a low (LF; n = 10)- or high-fat (HF; n = 11) diet for 17 wk. During week 15 of the study, arterial pressure was measured directly, 24 h/day, from chronically indwelling catheters. Body and kidney weights were 46 ± 5 and 33 ± 5% greater, respectively, in rats fed HF vs. LF diet. Left and right ventricular weights were also greater in rats fed HF diet (21 ± 7 and 36 ± 6%, respectively). Direct measurement of arterial pressure revealed only a slight increase in mean arterial pressure (88 ± 1 in rats fed HF diet vs. 85 ± 1 mmHg in rats fed LF diet), whereas there was no difference in resting heart rate between the two groups. Consumption of HF diet was also associated with a 3.5-fold increase in plasma insulin, a 16 ± 4% higher blood glucose, and a 40 ± 6% reduction in plasma renin activity compared with LF-fed rats. Thus feeding OM rats HF diet led to obesity, cardiac and renal hypertrophy, and hyperinsulinemia but only a slight increase in mean arterial pressure.

hypertension; cardiac hypertrophy


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