AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 281: R553-R560, 2001;
0363-6119/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (22)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Martin, D. S.
Right arrow Articles by Williams, J. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Martin, D. S.
Right arrow Articles by Williams, J. L.
Vol. 281, Issue 2, R553-R560, August 2001

Dietary soy exerts an antihypertensive effect in spontaneously hypertensive female rats

D. S. Martin, N. P. Breitkopf, K. M. Eyster, and J. L. Williams

Division of Basic Biomedical Sciences, School of Medicine University of South Dakota, Vermillion, South Dakota 57069

This study tested the hypothesis that dietary soy would attenuate the development of hypertension in female spontaneously hypertensive rats (SHR). Female SHR and control Wistar-Kyoto rats were obtained at 4 wk of age, randomly assigned to either an ovariectomized (OVX) group or a sham-operated group, and placed on a soy diet or control casein diet. After a minimum of 8 wk on their respective diets, mean arterial pressure (MAP) and heart rate (HR) were recorded before and after inhibition of nitric oxide synthase, air-jet stress, or ganglionic blockade. The major finding of this study is that MAP was reduced in the OVX SHR consuming soy diet compared with the casein-fed controls (150 ± 4 vs. 164 ± 3 mmHg). Plasma genistein concentrations were increased in the soy-fed OVX SHR (1.23 ± 0.31 µM) compared with the casein-fed OVX SHR (nondetectable). However, there was no difference in plasma genistein concentrations between sham-operated and OVX SHR (1.37 ± 0.42 vs. 1.23 ± 0.31 µM). Inhibition of nitric oxide synthase increased MAP and decreased HR in all groups; diet did not affect this response. Air-jet stress increased MAP and HR in all groups. However, these responses were exaggerated in the soy-fed SHR. Finally, ganglionic blockade abolished the antihypertensive effect of soy diet in the OVX SHR. These findings indicate that dietary soy exerts an antihypertensive effect in OVX SHR. This effect does not involve the nitric oxide system but may be related to an as yet undefined interaction with the autonomic nervous system.

isoflavones; genistein; hypertension


This article has been cited by other articles:


Home page
 J. Physiol.Home page
G. Douglas, J. A. Armitage, P. D. Taylor, J. R. Lawson, G. E. Mann, and L. Poston
Cardiovascular consequences of life-long exposure to dietary isoflavones in the rat
J. Physiol., March 1, 2006; 571(2): 477 - 487.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. Souzeau, S. Belanger, S. Picard, and C. F. Deschepper
Dietary isoflavones during pregnancy and lactation provide cardioprotection to offspring rats in adulthood
Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H715 - H721.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
S. Kreijkamp-Kaspers, L. Kok, M. L Bots, D. E Grobbee, J. W Lampe, and Y. T van der Schouw
Randomized controlled trial of the effects of soy protein containing isoflavones on vascular function in postmenopausal women
Am. J. Clinical Nutrition, January 1, 2005; 81(1): 189 - 195.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. C. Rodrigo, D. S. Martin, and K. M. Eyster
Estrogen decreases biglycan mRNA expression in resistance blood vessels
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2003; 285(4): R754 - R761.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online