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Am J Physiol Regul Integr Comp Physiol 281: R615-R624, 2001;
0363-6119/01 $5.00
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Vol. 281, Issue 2, R615-R624, August 2001

Differential role of adrenoceptors in control of plasma glucose and fatty acids in carp, Cyprinus carpio (L.)

Guido Van Den Thillart1, Gerjanne Vianen1, Maiza Campos Ponce1, Harm Lelieveld1, Maaike Nieveen1, Marcel Van Raaij1, Anton Steffens2, and Johan Zaagsma3

1 Institute of Evolutionary and Ecological Sciences, Van der Klaauw Laboratories, 2300 RA Leiden; 2 Department of Animal Physiology, University of Groningen, 9750 AA Haren; and 3 Department of Molecular Pharmacology, University of Groningen, 9713 AV Groningen, The Netherlands

Carp were cannulated in the dorsal aorta, and after 2 days of recovery they were infused with 1) norepinephrine, 2) yohimbine (alpha 2-antagonist) plus norepinephrine, 3) clonidine (alpha 2-agonist), and 4) isoproterenol (nonselective beta -agonist). Norepinephrine lowered the plasma free fatty acid (FFA) level and raised the plasma glucose level for several hours. Norepinephrine in combination with the alpha 2-antagonist yohimbine resulted in retardation of the FFA decrease, indicating the involvement of alpha 2-adrenoceptors. Infusion with the partial alpha 2-agonist clonidine had a smaller effect. Infusion with isoproterenol caused a marked increase of glucose levels, and unexpectedly a decline of plasma FFA levels, indicating a direct involvement of beta -adrenoceptors. Combination of isoproterenol with either atenolol (beta 1-antagonist) or ICI-118,551 (beta 2-antagonist) showed that both beta 1- and beta 2-adrenoceptors were involved in the glucose release by isoproterenol. Remarkably, the decline of FFA levels was augmented in the presence of ICI-118,551, whereas with atenolol present plasma FFA levels were increased by isoproterenol. Thus it is concluded that in carp both beta 1- and beta 2-adrenoceptors mediate glucose release, whereas lipolysis is controlled by inhibitory beta 1-adrenoceptors and stimulatory beta 2-adrenoceptors, as well as by inhibitory alpha 2-adrenoceptors.

lipolysis; beta -blockers; glycogenolysis; fish; hypoxia survival


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