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Am J Physiol Regul Integr Comp Physiol 281: R625-R634, 2001;
0363-6119/01 $5.00
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Vol. 281, Issue 2, R625-R634, August 2001

Muscle sympathetic outflow during horizontal linear acceleration in humans

Jian Cui1, Satoshi Iwase1, Tadaaki Mano1, Naomi Katayama2, and Shigeo Mori2

1 Department of Autonomic Neuroscience and 2 Space Medicine Research Center, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan

To elucidate the effects of linear acceleration on muscle sympathetic nerve activity (MSNA) in humans, 16 healthy men were tested in a linear accelerator. Measurements of MSNA, electrocardiogram, blood pressure, and thoracic impedance were undertaken during linear acceleration. Sinusoidal linear acceleration with peak values at ±0.10, ±0.15, and ±0.20 G was applied in anteroposterior (±Gx, n = 10) or lateral (±Gy, n = 6) directions. The total activity and burst rate of MSNA decreased significantly during forward, backward, left, or right linear accelerations. The total activity of MSNA decreased to 50.5 ± 6.9, 52.5 ± 4.4, 71.2 ± 9.6, and 67.6 ± 8.2% from the baselines (100%) during linear accelerations with peak values at ±0.20 G in the four directions, respectively. These results suggest that dynamic stimulation of otolith organs in horizontal directions in humans might inhibit MSNA directly in order to quickly redistribute blood to muscles during postural reflexes induced by passive movement, which supports the concept that the vestibular system contributes to sympathetic regulation in humans.

muscle sympathetic nerve activity; vestibular stimulation; microneurography


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