AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 281: R666-R672, 2001;
0363-6119/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (27)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Song, C. K.
Right arrow Articles by Bartness, T. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Song, C. K.
Right arrow Articles by Bartness, T. J.
Vol. 281, Issue 2, R666-R672, August 2001

CNS sympathetic outflow neurons to white fat that express MEL receptors may mediate seasonal adiposity

C. Kay Song and Timothy J. Bartness

Department of Biology, Neurobiology and Behavior Program and National Science Foundation Center for Behavioral Neuroscience, Georgia State University, Atlanta, Georgia 30303 - 3083

Many animals show seasonal changes in adiposity that are triggered by changes in the photoperiod. For example, in short "winterlike" days, the nocturnal duration of pineal melatonin (MEL) secretion increases ultimately resulting in body fat decreases by Siberian hamsters. These decreases in body fat are mediated through increases in the sympathetic drive on white adipose tissue (WAT). The central nervous system (CNS) origins of the sympathetic outflow from brain to WAT include the suprachiasmatic nucleus (SCN), an area necessary for the reception of season-encoded MEL signals in Siberian hamsters. Therefore, we tested whether SCN neurons that are part of the sympathetic outflow to WAT also express MEL receptors (MEL1a). This was accomplished by labeling the sympathetic outflow from brain to WAT using a transsynaptic retrograde tract tracer, the pseudorabies virus (PRV), injected into inguinal WAT combined with labeling of brain MEL1a receptors using in situ hybridization. We found PRV-labeled neurons that also expressed MEL1a-receptor mRNA in several brain regions including the SCN. Thus the increased duration of MEL secretion in short days may increase MEL1a-receptor stimulation that, in turn, increases the sympathetic drive on WAT, thereby increasing lipolysis and decreasing adiposity.

adipose tissue; suprachiasmatic nucleus; pseudorabies virus; melatonin 1a receptor; sympathetic nervous system; obesity


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. Leitner and T. J. Bartness
Food deprivation-induced changes in body fat mobilization after neonatal monosodium glutamate treatment
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R775 - R783.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. A. Ivanova, D. A. Bechtold, S. M. Dupre, J. Brennand, P. Barrett, S. M. Luckman, and A. S. I. Loudon
Altered metabolism in the melatonin-related receptor (GPR50) knockout mouse
Am J Physiol Endocrinol Metab, January 1, 2008; 294(1): E176 - E182.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Giordano, C. K. Song, R. R. Bowers, J. C. Ehlen, A. Frontini, S. Cinti, and T. J. Bartness
White adipose tissue lacks significant vagal innervation and immunohistochemical evidence of parasympathetic innervation
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1243 - R1255.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. K. Song, R. M. Jackson, R. B. S. Harris, D. Richard, and T. J. Bartness
Melanocortin-4 receptor mRNA is expressed in sympathetic nervous system outflow neurons to white adipose tissue
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2005; 289(5): R1467 - R1476.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. R. Bowers, T. W. Gettys, V. Prpic, R. B. S. Harris, and T. J. Bartness
Short photoperiod exposure increases adipocyte sensitivity to noradrenergic stimulation in Siberian hamsters
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1354 - R1360.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. R. Bowers, W. T. L. Festuccia, C. K. Song, H. Shi, R. H. Migliorini, and T. J. Bartness
Sympathetic innervation of white adipose tissue and its regulation of fat cell number
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2004; 286(6): R1167 - R1175.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. O. Fetissov, M. M. Meguid, T. Sato, and L.-H. Zhang
Expression of dopaminergic receptors in the hypothalamus of lean and obese Zucker rats and food intake
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2002; 283(4): R905 - R910.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
T. J. Bartness, G. E. Demas, and C. K. Song
Seasonal Changes in Adiposity: the Roles of the Photoperiod, Melatonin and Other Hormones, and Sympathetic Nervous System
Experimental Biology and Medicine, June 1, 2002; 227(6): 363 - 376.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
W. A. Cupples
Regulation of body weight
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1264 - R1266.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. E. Demas, R. R. Bowers, T. J. Bartness, and T. W. Gettys
Photoperiodic regulation of gene expression in brown and white adipose tissue of Siberian hamsters (Phodopus sungorus)
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2002; 282(1): R114 - R121.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online