AJP - Regu AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 281: R699-R705, 2001;
0363-6119/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Piuhola, J.
Right arrow Articles by Ruskoaho, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Piuhola, J.
Right arrow Articles by Ruskoaho, H.
Vol. 281, Issue 3, R699-R705, September 2001

Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1

Jarkko Piuhola1, Annette Hammes2, Kai Schuh3, Ludwig Neyses3, Olli Vuolteenaho4, and Heikki Ruskoaho1

Departments of 1 Pharmacology and Toxicology and 4 Physiology, Biocenter Oulu, FIN-90014 University of Oulu, Finland; 2 Max-Delbrück Center for Molecular Medicine, 13092 Berlin; and 3 Department of Medicine, University of Würzburg, D-97080 Würzburg, Germany

The function of the plasma membrane calmodulin-dependent calcium ATPase (PMCA) in myocardium is unknown. PMCA is localized in caveolae, 50- to 100-nm membrane invaginations, which also contain receptors for endothelin-1 (ET-1) and various other ligands. PMCA has been suggested to play a role in regulation of caveolar signal transduction. We studied the effects of the hypertrophic agonist ET-1 and increased coronary perfusion pressure on cardiac synthesis of B-type natriuretic peptide (BNP) in transgenic rats overexpressing the human PMCA 4CI in isolated perfused heart preparation. ET-1 infusion for 2 h increased BNP mRNA levels twofold in left ventricles (LV) of nontransgenic rats, whereas no increase was noted in PMCA rat hearts. Similar responses were seen in adrenomedullin and c-fos mRNA levels, and in immunoreactive BNP secretion. Increased mechanical load produced by elevated perfusion pressure induced similar 1.5- to 1.6-fold increases in LV BNP mRNA in both nontransgenic and PMCA rat hearts. These results show that cardiac overexpression of PMCA attenuates ET-1-stimulated early induction of cardiac gene expression, suggesting that PMCA may modulate myocardial growth responses.

plasma membrane Ca2+-ATPase; natriuretic peptides; adrenomedullin


This article has been cited by other articles:


Home page
 CirculationHome page
D. Oceandy, E. J. Cartwright, M. Emerson, S. Prehar, F. M. Baudoin, M. Zi, N. Alatwi, L. Venetucci, K. Schuh, J. C. Williams, et al.
Neuronal Nitric Oxide Synthase Signaling in the Heart Is Regulated by the Sarcolemmal Calcium Pump 4b
Circulation, January 30, 2007; 115(4): 483 - 492.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. P. Granger
Endothelin
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2003; 285(2): R298 - R301.
[Full Text] [PDF]

Home page
 HypertensionHome page
J. Piuhola, I. Szokodi, P. Kinnunen, M. Ilves, R. deChatel, O. Vuolteenaho, and H. Ruskoaho
Endothelin-1 Contributes to the Frank-Starling Response in Hypertrophic Rat Hearts
Hypertension, January 1, 2003; 41(1): 93 - 98.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online