AJP - Regu Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 281: R730-R737, 2001;
0363-6119/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (52)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Conesa, E. L.
Right arrow Articles by Salom, M. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Conesa, E. L.
Right arrow Articles by Salom, M. G.
Vol. 281, Issue 3, R730-R737, September 2001

N-acetyl-L-cysteine improves renal medullary hypoperfusion in acute renal failure

Erica López Conesa1, Fernando Valero2, José Carlos Nadal2, Francisco J. Fenoy2, Bernardo López2, Begoña Arregui2, and Miguel García Salom2

1 Iffa-Credo, Domaine des Oncins, BP 0109, 69592 L'Arbresle Cedex, France; and 2 Departamento de Fisiología y Farmacología, Facultad de Medicina, 30100 Murcia, Spain

This study evaluated the effects of N-acetyl-L-cysteine (NAC), a free radical scavenger, and Nomega -nitro-L-arginine methyl ester (L-NAME), a nitric oxide (NO) synthesis inhibitor, on the changes in renal function, intrarenal blood flow distribution (laser-Doppler flowmetry), and plasma peroxynitrite levels during the acute renal failure (ARF) produced by inferior vena cava occlusion (IVCO; 45 min) in anesthetized rats. Renal blood flow fell on reperfusion (whole kidney by -45.7%; cortex -58.7%, outer medulla -62.8%, and papilla -47.7%); glomerular filtration rate (GRF) also decreased (-68.6%), whereas fractional sodium excretion (FENa%) and peroxynitrite and NO<UP><SUB>2</SUB><SUP>−</SUP></UP>/NO<UP><SUB>3</SUB><SUP>−</SUP></UP> plasma levels increased (189.5, 46.5, and 390%, respectively) after ischemia. Pretreatment with L-NAME (10 µg · kg-1 · min-1) aggravated the fall in renal blood flow seen during reperfusion (-60%). Pretreatment with NAC (150 mg/kg bolus + 715 µg · kg-1 · min-1 iv) partially prevented those changes in renal function (GFR only fell by -29.2%, and FENa% increased 119.4%) and laser-Doppler blood flow, especially in the outer medulla, where blood flow recovered to near control levels during reperfusion. These beneficial effects seen in rats given NAC seem to be dependent on the presence of NO, because they were abolished in rats pretreated with L-NAME. Also, the antioxidant effects of NAC prevented the increase in plasma peroxynitrite after ischemia. In conclusion, NAC ameliorates the renal failure and the outer medullary vasoconstriction induced by ICVO, effects that seem to be dependent on the presence of NO and the scavenging of peroxynitrite.

inferior vena cava occlusion; free radical scavengers; peroxynitrite; nitric oxide; plasma nitrite/nitrate; renal function; laser-Doppler flowmetry


This article has been cited by other articles:


Home page
 CJASNHome page
S. Fishbane
N-Acetylcysteine in the Prevention of Contrast-Induced Nephropathy
Clin. J. Am. Soc. Nephrol., January 1, 2008; 3(1): 281 - 287.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. G. Salom, S. Nieto Ceron, F. Rodriguez, B. Lopez, I. Hernandez, J. Gil Martinez, A. Martinez Losa, and F. J. Fenoy
Heme oxygenase-1 induction improves ischemic renal failure: role of nitric oxide and peroxynitrite
Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3542 - H3549.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
N. Nitescu, S.-E. Ricksten, N. Marcussen, B. Haraldsson, U. Nilsson, S. Basu, and G. Guron
N-acetylcysteine attenuates kidney injury in rats subjected to renal ischaemia-reperfusion
Nephrol. Dial. Transplant., May 1, 2006; 21(5): 1240 - 1247.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. de Araujo, L. Andrade, T. M. Coimbra, A. C. Rodrigues Jr, and A. C. Seguro
Magnesium Supplementation Combined with N-Acetylcysteine Protects against Postischemic Acute Renal Failure
J. Am. Soc. Nephrol., November 1, 2005; 16(11): 3339 - 3349.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. G. Salom, B. Arregui, L. F. Carbonell, F. Ruiz, J. L. Gonzalez-Mora, and F. J. Fenoy
Renal ischemia induces an increase in nitric oxide levels from tissue stores
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2005; 289(5): R1459 - R1466.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. Fishbane, J. H. Durham, K. Marzo, and M. Rudnick
N-Acetylcysteine In The Prevention Of Radiocontrast-Induced Nephropathy
J. Am. Soc. Nephrol., February 1, 2004; 15(2): 251 - 260.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. B. Persson
The kidney and hypertension
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2003; 284(5): R1176 - R1178.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. B. Persson
Nitric oxide in the kidney
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2002; 283(5): R1005 - R1007.
[Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
H. Hercule and A. Oyekan
Renal Cytochrome P450 Oxygenases and Preglomerular Vascular Response to Arachidonic Acid and Endothelin-1 Following Ischemia/Reperfusion
J. Pharmacol. Exp. Ther., August 1, 2002; 302(2): 717 - 724.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online