AJP - Regu Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 281: R828-R838, 2001;
0363-6119/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (27)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kubota, T.
Right arrow Articles by Krueger, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kubota, T.
Right arrow Articles by Krueger, J. M.
Vol. 281, Issue 3, R828-R838, September 2001

Interleukin-18 promotes sleep in rabbits and rats

Takeshi Kubota, Jidong Fang, Richard A. Brown, and James M. Krueger

Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164 - 6520

Interleukin (IL)-1beta is involved in physiological sleep regulation. IL-18 is a member of the IL-1 family, and its signal-transduction mechanism is similar to that of IL-1. Therefore, we hypothesized that IL-18 might also be involved in sleep regulation. Three doses of IL-18 (10, 100, and 500 ng) were injected intracerebroventricularly (icv) into rabbits at the onset of the dark period. The two higher doses of IL-18 markedly increased non-rapid eye movement sleep (NREMS), accompanied by increases in brain temperature (Tbr). These effects were lost after the heat inactivation of IL-18. The 500 ng of IL-18 injection during the light period also increased NREMS and Tbr. Similar results were obtained after icv injection of 100 ng of IL-18 into rats. Furthermore, intraperitoneal injection of 30 µg/kg of IL-18 slightly, but significantly, increased NREMS, whereas it significantly decreased electroencephalogram slow-wave activity in rats. Intraperitoneal IL-18 failed to induce fever. An anti-human IL-18 antibody had little effect on spontaneous sleep in rabbits, although the anti-IL-18 antibody significantly attenuated muramyl dipeptide-induced sleep. These data suggest that IL-18 is involved in mechanisms of sleep responses to infection.

electroencephalogram; cytokine; muramyl dipeptide


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
J.-Y. Yang, J.-W. Huang, C.-K. Chiang, C.-C. Pan, K.-D. Wu, T.-J. Tsai, and W.-Y. Chen
Higher plasma interleukin-18 levels associated with poor quality of sleep in peritoneal dialysis patients
Nephrol. Dial. Transplant., December 1, 2007; 22(12): 3606 - 3609.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Imeri, S. Bianchi, and M. R. Opp
Inhibition of caspase-1 in rat brain reduces spontaneous nonrapid eye movement sleep and nonrapid eye movement sleep enhancement induced by lipopolysaccharide
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2006; 291(1): R197 - R204.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Yoshida, T. Kubota, and J. M. Krueger
A cyclooxygenase-2 inhibitor attenuates spontaneous and TNF-{alpha}-induced non-rapid eye movement sleep in rabbits
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2003; 285(1): R99 - R109.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Scholz
Fever
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R913 - R915.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. Gatti, J. Beck, G. Fantuzzi, T. Bartfai, and C. A. Dinarello
Effect of interleukin-18 on mouse core body temperature
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2002; 282(3): R702 - R709.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online