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Am J Physiol Regul Integr Comp Physiol 281: R855-R860, 2001;
0363-6119/01 $5.00
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Vol. 281, Issue 3, R855-R860, September 2001

Parathyroid hormone-related protein: a calcium regulatory factor in sea bream (Sparus aurata L.) larvae

Pedro M. Guerreiro1,2,*, Juan Fuentes1,*, Deborah M. Power1, Patricia M. Ingleton3, Gert Flik2, and Adelino V. M. Canario1

1 Centre of Marine Sciences, University of Algarve, Campus de Gambelas, 8000 - 810 Faro, Portugal; 3 Division of Musculo-Skeletal Medicine, Institute of Endocrinology, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, United Kingdom; and 2 Department of Animal Physiology, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands

The effects of an N-terminal peptide (amino acids 1-38) of Fugu parathyroid hormone-related protein (PTHrP 1-38) on calcium regulation of larval sea bream were investigated in seawater (36per thousand ) and after transfer to dilute seawater (12per thousand ). Exposure to PTHrP 1-38 evoked a 1.5-fold increase in calcium influx in both full-strength and dilute seawater. Calcium influx in dilute seawater-adapted larvae was roughly one-half that observed in full-strength seawater controls. PTHrP 1-38 also reduced drinking of fish in seawater but, at all concentrations tested, was without effect in dilute seawater. The amount of water imbibed was 55% lower in dilute seawater than in seawater. PTHrP 1-38 exposure affected the calcium influx route: the main contribution of calcium uptake shifted from intestinal absorption to extraintestinal uptake, probably by the induction of a dose-dependent increase in branchial (active) transport. Moreover, seawater-adapted fish exposed to 1 nM and 10 mM PTHrP 1-38 experienced a 2.5-fold reduction in overall calcium efflux. Overall, the calciotropic action of PTHrP 1-38 resulted in a dose-dependent increase in net calcium balance.

hypercalcemia

* P. M. Guerreiro and J. Fuentes contributed equally to this work.




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