AJP - Regu AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 281: R894-R901, 2001;
0363-6119/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stephens, D. P.
Right arrow Articles by Saumet, J. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stephens, D. P.
Right arrow Articles by Saumet, J. L.
Vol. 281, Issue 3, R894-R901, September 2001

The influence of topical capsaicin on the local thermal control of skin blood flow in humans

Dan P. Stephens1, Nisha Charkoudian1, Jessica M. Benevento2, John M. Johnson1, and Jean Louis Saumet3

1 The University of Texas Health Science Center, Department of Physiology, San Antonio 78229; 2 Texas Lutheran University, Seguin, Texas 78155; and 3 Laboratoire de Physiologie et d'Explorations Vasculaires, Centre Hospitalier Universitaire d'Angers, 49045 Angers Cedex 01, France

To test whether heat-sensitive receptors participate in the cutaneous vascular responses to direct heating, we monitored skin blood flow (SkBF; laser Doppler flowmetry) where the sensation of heat was induced either by local warming (TLoc; Peltier cooling/heating unit) or by both direct warming and chemical stimulation of heat-sensitive nociceptors (capsaicin). In part I, topical capsaicin (0.075 or 0.025%) was applied to 12 cm2 of skin 1 h before stepwise local warming of untreated and capsaicin-treated forearm skin. Pretreatment with 0.075% capsaicin cream shifted the SkBF/TLoc relationship to lower temperatures by an average of 6 ± 0.8°C (P < 0.05). In part II, we used a combination of topical capsaicin (0.025%) and local warming to evoke thermal sensation at one site and only local warming to evoke thermal sensation at a separate site. Cutaneous vasomotor responses were compared when the temperatures at these two sites were perceived to be the same. SkBF differed significantly between capsaicin and control sites when compared on the basis of actual temperatures, but that difference became insignificant when compared on the basis of the perceived temperatures. These data suggest heat-sensitive nociceptors are important in the cutaneous vasodilator response to local skin warming.

nociceptors; warmth perception; laser Doppler; local warming


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. J. Joyner
Cutaneous blood flow: uncomfortable in our own skin?
Am J Physiol Heart Circ Physiol, January 1, 2009; 296(1): H29 - H30.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. L. Kellogg Jr., J. L. Zhao, and Y. Wu
Endothelial nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo
Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H123 - H129.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
D. Roosterman, T. Goerge, S. W. Schneider, N. W. Bunnett, and M. Steinhoff
Neuronal control of skin function: the skin as a neuroimmunoendocrine organ.
Physiol Rev, October 1, 2006; 86(4): 1309 - 1379.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. L. Kellogg Jr
In vivo mechanisms of cutaneous vasodilation and vasoconstriction in humans during thermoregulatory challenges
J Appl Physiol, May 1, 2006; 100(5): 1709 - 1718.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. M. Johnson, T. C. Yen, K. Zhao, and W. A. Kosiba
Sympathetic, sensory, and nonneuronal contributions to the cutaneous vasoconstrictor response to local cooling
Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1573 - H1579.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. O. Warner, M. J. Joyner, and N. Charkoudian
Nicotine increases initial blood flow responses to local heating of human non-glabrous skin
J. Physiol., September 15, 2004; 559(3): 975 - 984.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. A. Munce and W. L. Kenney
Age-specific modification of local cutaneous vasodilation by capsaicin-sensitive primary afferents
J Appl Physiol, September 1, 2003; 95(3): 1016 - 1024.
[Abstract] [Full Text] [PDF]

Home page
 Mayo Clin Proc.Home page
N. Charkoudian
Skin Blood Flow in Adult Human Thermoregulation: How It Works, When It Does Not, and Why
Mayo Clin. Proc., May 1, 2003; 78(5): 603 - 612.
[Abstract] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
T. A. Munce and W. L. Kenney
Age-Specific Skin Blood Flow Responses to Acute Capsaicin
J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2003; 58(4): B304 - 310.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
V. Moiseenkova, B. Bell, M. Motamedi, E. Wozniak, and B. Christensen
Wide-band spectral tuning of heat receptors in the pit organ of the copperhead snake (Crotalinae)
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R598 - R606.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online