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Am J Physiol Regul Integr Comp Physiol 281: R894-R901, 2001;
0363-6119/01 $5.00
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Vol. 281, Issue 3, R894-R901, September 2001

The influence of topical capsaicin on the local thermal control of skin blood flow in humans

Dan P. Stephens1, Nisha Charkoudian1, Jessica M. Benevento2, John M. Johnson1, and Jean Louis Saumet3

1 The University of Texas Health Science Center, Department of Physiology, San Antonio 78229; 2 Texas Lutheran University, Seguin, Texas 78155; and 3 Laboratoire de Physiologie et d'Explorations Vasculaires, Centre Hospitalier Universitaire d'Angers, 49045 Angers Cedex 01, France

To test whether heat-sensitive receptors participate in the cutaneous vascular responses to direct heating, we monitored skin blood flow (SkBF; laser Doppler flowmetry) where the sensation of heat was induced either by local warming (TLoc; Peltier cooling/heating unit) or by both direct warming and chemical stimulation of heat-sensitive nociceptors (capsaicin). In part I, topical capsaicin (0.075 or 0.025%) was applied to 12 cm2 of skin 1 h before stepwise local warming of untreated and capsaicin-treated forearm skin. Pretreatment with 0.075% capsaicin cream shifted the SkBF/TLoc relationship to lower temperatures by an average of 6 ± 0.8°C (P < 0.05). In part II, we used a combination of topical capsaicin (0.025%) and local warming to evoke thermal sensation at one site and only local warming to evoke thermal sensation at a separate site. Cutaneous vasomotor responses were compared when the temperatures at these two sites were perceived to be the same. SkBF differed significantly between capsaicin and control sites when compared on the basis of actual temperatures, but that difference became insignificant when compared on the basis of the perceived temperatures. These data suggest heat-sensitive nociceptors are important in the cutaneous vasodilator response to local skin warming.

nociceptors; warmth perception; laser Doppler; local warming


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