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2-receptor
function in vascular adrenergic nerves of adult and fetal
sheep
1 Department of Physiology and Pharmacology, School of Medicine, Loma Linda University, Loma Linda 92350; and 2 Department of Pharmacology, College of Medicine, University of California, Irvine, California 92697
The
impact of development and chronic high-altitude hypoxia on the function
of prejunctional 
2-adrenoceptors was studied by
measuring norepinephrine release in vitro from fetal and adult sheep
middle cerebral and facial arteries. Blockade of prejunctional 2-adrenoceptors with idazoxan significantly increased
stimulation-evoked norepinephrine release in normoxic arteries. This
effect was eliminated after chronic hypoxia in cerebral arteries, with
a tendency to decline in fetal facial arteries. After chronic hypoxia,
the capacity to release norepinephrine declined in fetal middle
cerebral arteries with a similar trend in facial arteries.
Norepinephrine release was maintained in adult arteries. During
development, stimulation-evoked norepinephrine release from middle
cerebral and facial arteries was higher compared with adult arteries.
In fetal arteries, adrenergic nerve function declined after chronic
hypoxia. However, in adult arteries, adrenergic nerves adapted to
chronic hypoxia by maintaining overall function. This differential
adaptation of adrenergic nerves in fetal arteries may reflect
differences in fetal distribution of blood flow in response to chronic
hypoxic stress.
sympathetic nerve function
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