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Am J Physiol Regul Integr Comp Physiol 281: R960-R970, 2001;
0363-6119/01 $5.00
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Vol. 281, Issue 3, R960-R970, September 2001

Programming effects in sheep of prenatal growth restriction and glucocorticoid exposure

Timothy J. M. Moss1,2, Deborah M. Sloboda3, Lyle C. Gurrin1,2, Richard Harding4, John R. G. Challis3, and John P. Newnham1,2

1 Department of Obstetrics and Gynaecology, The University of Western Australia, Perth, WA 6009; 2 Womens and Infants Research Foundation, Perth, WA 6008; 4 Fetal and Neonatal Research Unit, Department of Physiology, Monash University, Victoria, Australia 3800; and 3 Medical Research Council Group in Fetal and Neonatal Health and Development, Department of Physiology, University of Toronto, Ontario, Canada M5S 1A8

Our aim was to determine the postnatal effects of single and repeated glucocorticoid injections during late gestation. Repeated (104, 111, 118, 125 days) or single (104 days) injections of betamethasone or saline were given to the ewe or by ultrasound guided injection to the fetus (term 150 days). Lambs were born spontaneously and studied at 3 and 6 mo and 1 yr of age. Arterial pressure was measured at each age, and we performed intravenous glucose tolerance tests at 6 mo and 1 yr. Repeated maternal, but not single maternal or fetal, betamethasone injections prolonged gestation, reduced weight at birth and 3 mo, and was associated with low arterial pressure at 3 mo but not at 6 mo and 1 yr. Glucose metabolism was altered in all betamethasone treatment groups, regardless of the number or route of injections. Our data demonstrate that glucocorticoid-induced fetal growth restriction is associated with a transient reduction in postnatal arterial pressure, but glucocorticoid exposure with or without growth restriction alters glucose metabolism.

antenatal glucocorticoids; betamethasone; fetal intervention; intrauterine growth restriction


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