| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of 1 Pediatrics, 5 Physiology and Biophysics, and 4 Medicine, Georgetown University Medical Center, Washington, District of Columbia 20007; 2 Zambon Group, 20091 Bresso (MI), Italy; and 3 Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892
D1-like (D1, D5) and
D2-like (D2, D3, D4)
dopamine receptors interact in the kidney to produce a natriuresis and
a diuresis. Disruption of D1 or D3 receptors in
mice results in hypertension that is caused, in part, by a decreased
ability to excrete an acute saline load. We studied
D1-like and D2-like receptor interaction in
anesthetized spontaneously hypertensive rats (SHR) by the
intrarenal infusion of Z-1046 (a novel dopamine receptor
agonist with rank order potency of
D3
D4>D2>D5>D1).
Z-1046 increased glomerular filtration rate (GFR), urine flow, and
sodium excretion in normotensive Wistar-Kyoto rats but not in SHRs. The
lack of responsiveness to Z-1046 in SHRs was not an epiphenomenon,
because intrarenal cholecystokinin infusion increased GFR, urine flow,
and sodium excretion to a similar extent in the two rat strains. We
conclude that renal D1-like and D2-like
receptor interaction is impaired in SHRs. The impaired
D1-like and D2-like receptor interaction in
SHRs is not caused by alterations in the coding sequence of the
D3 receptor, the D2-like receptor expressed in
rat renal tubules that has been shown to be involved in sodium
transport. Because the diuretic and natriuretic effects of
D1-like receptors are, in part, caused by an interaction
with D2-like receptors, it is possible that the decreased
Z-1046 action in SHRs is secondary to the renal D1-like
receptor dysfunction in this rat strain.
D1-like receptors; D2-like receptors; natriuresis; diuresis; cholecystokinin; hypertension
This article has been cited by other articles:
|
|
 |
|
  C. Zeng, I. Armando, Y. Luo, G. M. Eisner, R. A. Felder, and P. A. Jose Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H551 - H569. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Zeng, Y. Liu, Z. Wang, D. He, L. Huang, P. Yu, S. Zheng, J. E. Jones, L. D. Asico, U. Hopfer, et al. Activation of D3 Dopamine Receptor Decreases Angiotensin II Type 1 Receptor Expression in Rat Renal Proximal Tubule Cells Circ. Res., September 1, 2006; 99(5): 494 - 500. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Zeng, Z. Yang, Z. Wang, J. Jones, X. Wang, J. Altea, A. J. Mangrum, U. Hopfer, D. R. Sibley, G. M. Eisner, et al. Interaction of Angiotensin II Type 1 and D5 Dopamine Receptors in Renal Proximal Tubule Cells Hypertension, April 1, 2005; 45(4): 804 - 810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Zeng, H. Sanada, H. Watanabe, G. M. Eisner, R. A. Felder, and P. A. Jose Functional genomics of the dopaminergic system in hypertension Physiol Genomics, November 17, 2004; 19(3): 233 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zeng, Y. Luo, L. D. Asico, U. Hopfer, G. M. Eisner, R. A. Felder, and P. A. Jose Perturbation of D1 Dopamine and AT1 Receptor Interaction in Spontaneously Hypertensive Rats Hypertension, October 1, 2003; 42(4): 787 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Felder, H. Sanada, J. Xu, P.-Y. Yu, Z. Wang, H. Watanabe, L. D. Asico, W. Wang, S. Zheng, I. Yamaguchi, et al. G protein-coupled receptor kinase 4 gene variants in human essential hypertension PNAS, March 19, 2002; 99(6): 3872 - 3877. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
