AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 281: R1215-R1223, 2001;
0363-6119/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mollanji, R.
Right arrow Articles by Johnston, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mollanji, R.
Right arrow Articles by Johnston, M.
Vol. 281, Issue 4, R1215-R1223, October 2001

Comparison of cerebrospinal fluid transport in fetal and adult sheep

R. Mollanji1, C. Papaiconomou1, M. Boulton1, R. Midha2, and M. Johnston1

1 Trauma Research Program, Department of Laboratory Medicine and Pathobiology and 2 Division of Neurosurgery, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario M4N 3M5, Canada

We quantified cerebrospinal fluid (CSF) transport (conductance) and CSF outflow resistance in late-gestation fetal and adult sheep using two methods, a constant pressure infusion method and a bolus injection technique into the lateral ventricles. No significant differences in CSF conductance (fetus 0.013 ± 0.002, adult 0.014 ± 0.003 ml · min-1 · cmH2O-1) or CSF outflow resistance (fetus 83.7 ± 9.8, adult 84.7 ± 19.7 cmH2O · ml-1 · min) were observed. To confirm CSF transport to plasma in fetal animals, 125I- or 131I-labeled human serum albumin (HSA) was injected into the lateral ventricles. The tracer entered fetal plasma with an average mass transport rate of 1.91 ± 0.47% injected/h (n = 9). In two fetuses, we monitored the tracer appearance in plasma and cervical and thoracic duct lymph after injection of radioactive HSA into the ventricular CSF. As was the case in adult animals, fetal tracer concentrations increased in all three compartments over time, with the highest concentrations measured in lymph collected from the cervical lymphatics. These results 1) indicate that global CSF transport parameters in the late-gestation fetus and adult sheep are similar and 2) suggest an important role for extracranial lymphatic vessels in CSF transport before birth.

arachnoid villi; lymphatic vessels; intracranial pressure; cerebrospinal fluid pressure; fetal cerebrospinal fluid outflow resistance; fetal cerebrospinal fluid conductance; cribriform plate; hydrocephalus


This article has been cited by other articles:


Home page
 PhysiologyHome page
M. Johnston and C. Papaiconomou
Cerebrospinal Fluid Transport: a Lymphatic Perspective
Physiology, December 1, 2002; 17(6): 227 - 230.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. P. Granger
Maternal and fetal adaptations during pregnancy: lessons in regulatory and integrative physiology
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2002; 283(6): R1289 - R1292.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. Papaiconomou, R. Bozanovic-Sosic, A. Zakharov, and M. Johnston
Does neonatal cerebrospinal fluid absorption occur via arachnoid projections or extracranial lymphatics?
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2002; 283(4): R869 - R876.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. Mollanji, R. Bozanovic-Sosic, A. Zakharov, L. Makarian, and M. G. Johnston
Blocking cerebrospinal fluid absorption through the cribriform plate increases resting intracranial pressure
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1593 - R1599.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online