AJP - Regu Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 281: R1290-R1294, 2001;
0363-6119/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Geary, N.
Right arrow Articles by Asarian, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Geary, N.
Right arrow Articles by Asarian, L.
Vol. 281, Issue 4, R1290-R1294, October 2001

Estradiol increases glucagon's satiating potency in ovariectomized rats

Nori Geary and Lori Asarian

Department of Psychiatry, Joan and Sanford I. Weill Medical College of Cornell University, New York 10021; and Edward W. Bourne Behavioral Research Laboratory, The New York Presbyterian Hospital-Cornell Medical Center, White Plains, New York 10605

Estradiol decreases meal size, food intake, and body weight in female rats. To investigate whether these effects of estradiol involve a change in the sensitivity of the signaling pathway through which pancreatic glucagon released during meals contributes to meal termination (satiation), glucagon or glucagon antibodies were infused via the hepatic portal vein in ovariectomized rats that were chronically treated with estradiol benzoate (2 µg/day sc) or vehicle alone (100 µl sesame oil). Infusions began at 1 h after dark onset, as rats were refed after 7 h of food deprivation. Glucagon (3 µg/min for 30 min) decreased feeding during the initial 45 min of food access in both groups of rats, but the inhibition was significantly greater in estradiol- than in oil-treated rats. Similarly, antagonism of endogenous glucagon by infusion of glucagon antibodies (a dose neutralizing 3 ng of glucagon in vitro during the first 3 min of refeeding) increased feeding significantly more in estradiol- than in oil-treated rats. These data indicate that an increase in the activity of the endogenous glucagon satiation-signaling pathway may be part of the mechanism for estradiol's inhibitory effect on feeding.

feeding; satiety; gender differences; meal size; ovarian hormones


This article has been cited by other articles:


Home page
 J. Nutr.Home page
J. M. Y. Jiang, S. M. Sacco, and W. E. Ward
Ovariectomy-Induced Hyperphagia Does Not Modulate Bone Mineral Density or Bone Strength in Rats
J. Nutr., November 1, 2008; 138(11): 2106 - 2110.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
S. C Woods, T. A Lutz, N. Geary, and W. Langhans
Pancreatic signals controlling food intake; insulin, glucagon and amylin
Phil Trans R Soc B, July 29, 2006; 361(1471): 1219 - 1235.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
W. A. Cupples
Regulating food intake
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2003; 284(3): R652 - R654.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
W. A. Cupples
Regulation of body weight
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1264 - R1266.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online