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Am J Physiol Regul Integr Comp Physiol 281: R1302-R1310, 2001;
0363-6119/01 $5.00
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Vol. 281, Issue 4, R1302-R1310, October 2001

Analysis of the afferent limb of the vesicovascular reflex using neurotoxins, resiniferatoxin and capsaicin

Yao-Chi Chuang, Matthew O. Fraser, Yongbei Yu, Jonathan M. Beckel, Satoshi Seki, Yasukazu Nakanishi, Hitoshi Yokoyama, Michael B. Chancellor, Naoki Yoshimura, and William C. de Groat

Departments of Pharmacology and Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261; Division of Urology, Chang Gung Memorial Hospital, Kaohsiung 833; and Department of Urology, National Yang Ming University, School of Medicine, Taipei 155, Taiwan

The afferent limb of the vesicovascular reflex (VV-R) evoked by distension or contraction of the urinary bladder (UB) was studied in urethane-anesthetized female rats by examining the changes in VV-R after administration of C-fiber afferent neurotoxins [capsaicin and resiniferatoxin (RTX)]. Systemic arterial blood pressure increased parallel (5.1 to 53.7 mmHg) with graded increases in UB pressure (20 to 80 cmH2O) or during UB contractions. The arterial pressor response to UB distension was significantly reduced (60-85%) by acute or chronic (4 days earlier) intravesical administration of RTX (100-1,000 nM) or by capsaicin (125 mg/kg sc) pretreatment (4 days earlier). Chronic neurotoxin treatments also increased the volume threshold (>100%) for eliciting micturition in anesthetized rats but did not change voiding pressure. Acute RTX treatment (10-50 nM) did not alter the arterial pressor response during reflex UB contractions, whereas higher concentrations of RTX (100-1,000 nM) blocked reflex bladder contractions. It is concluded that VV-R is triggered primarily by distension- and contraction-sensitive C-fiber afferents located, respectively, near the luminal surface and deeper in the muscle layers of the bladder.

urinary bladder; afferent nerve


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