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The John B. Pierce Laboratory and Departments of Epidemiology and Public Health and of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06519; and Women and Infants Hospital, Brown University School of Medicine, Providence, Rhode Island 02905
The purpose of this study was to determine estrogen
(E2) and progesterone (P4) effects on atrial
natriuretic peptide (ANP) control of plasma volume (PV) and
transcapillary fluid dynamics. To this end, we suppressed reproductive
function in 12 women (age 21-35 yr) using a gonadotropin
releasing-hormone (GnRH) analog (leuprolide acetate) for 5 wk. During
the 5th week, the women either received 4 days of E2
administration (17
-estradiol, transdermal patch, 0.1 mg/day) or 4 days of E2 with P4 administration (vaginal gel,
90 mg P4 twice per day). At the end of the 4th and 5th week of GnRH analog and hormone administration, we determined PV (Evans blue
dye) and changes in PV and forearm capillary filtration coefficient (CFC) during a 120-min infusion of ANP (5 ng · kg body
wt
1 · min1). Preinfusion PV was
estimated from Evans blue dye measurement taken over the last 30 min of
infusion based on changes in hematocrit. E2 treatment did
not affect preinfusion PV relative to GnRH analog alone (45.3 ± 3.1 vs. 45.4 ± 3.1 ml/kg). During ANP infusion CFC was greater
during E2 treatment compared with GnRH analog alone (6.5 ± 1.4 vs. 4.9 ± 1.4 µl · 100 g1 · min1 mmHg1,
P < 0.05). The %PV loss during ANP infusion was
similar for E2 and GnRH analog-alone treatments (
0.8 ± 0.2 and 1.0 ± 0.2 ml/kg, respectively), indicating the
change in CFC had little systemic effect on ANP-related changes in PV.
Estimated baseline PV was reduced by E2-P4
treatment. During ANP infusion CFC was ~30% lower during
E2-P4 (6.0 ± 0.5 vs. 4.3 ± 4.3 µl · 100 g1 · min1
mmHg1, P < 0.05), and the PV loss during
ANP infusion was attenuated (0.9 ± 0.2 and 0.2 ± 0.2 ml/kg for GnRH analog-alone and E2-P4 treatments, respectively). Thus the E2-P4
treatment lowered CFC and reduced PV loss during ANP infusion.
plasma volume; interstitial fluid; capillary filtration coefficient
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