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-2 adrenoreceptor modulation of
arterial chemoreflexes in the caudal solitary nucleus of the
rat
Department of Physiological Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida 32610-0144
The caudal region of
the nucleus of the solitary tract (cNTS) is the primary central
termination site for arterial chemoreceptor afferents originating from
the carotid body. The purpose of the present study was to investigate
the role of endogenous activation of 
-2 adrenoreceptors in the cNTS
on arterial chemoreflex function. Arterial chemoreflex responses to
intravenous injections of potassium cyanide (KCN; 75 µg/kg) were
recorded before and following blockade of -2 adrenoreceptors in the
cNTS of urethane-anesthetized rats. KCN alone elicited a reflex
increase in arterial pressure, renal sympathetic nerve activity, and
respiration. After bilateral cNTS microinjection of -2 receptor
antagonists (2 nmol idazoxan or 0.2 nmol yohimbine), arterial
chemoreflex responses were markedly attenuated. Attenuation of
chemoreflex function was not accompanied by any significant change in
resting blood pressure or respiratory rate. The results suggest that
the endogenous activation of -2 adrenoreceptors facilitates central
processing of chemoreceptor afferent inputs in the cNTS of the rat.
idazoxan; peripheral chemoreflex; arterial baroreflex; respiratory control; potassium cyanide
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