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Am J Physiol Regul Integr Comp Physiol 281: R1506-R1513, 2001;
0363-6119/01 $5.00
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Vol. 281, Issue 5, R1506-R1513, November 2001

Intracellular and extracellular calcium utilization during hypoxic vasoconstriction of cyclostome aortas

Michael J. Russell1, Nancy J. Pelaez2, C. Subah Packer2, Malcom E. Forster3, and Kenneth R. Olson1

1 Indiana University School of Medicine, South Bend Center for Medical Education, University of Notre Dame, Notre Dame 46556; 2 Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202; and 3 Department of Zoology, University of Canterbury, Private Bag 4800, Christchurch, New Zealand

Hypoxic vasoconstriction (HV) is an intrinsic response of mammalian pulmonary and cyclostome aortic vascular smooth muscle. The present study examined the utilization of calcium during HV in dorsal aortas (DA) from sea lamprey and New Zealand hagfish. HV was temporally correlated with increased free cytosolic calcium (Ca<UP><SUB>c</SUB><SUP>2+</SUP></UP>) in lamprey DA. Extracellular calcium (Ca<UP><SUB>o</SUB><SUP>2+</SUP></UP>) did not contribute significantly to HV in lamprey DA, but it accounted for 38.1 ± 5.3% of HV in hagfish DA. Treatment of lamprey DA with ionomycin, ryanodine, or caffeine added to thapsigargin-reduced HV, whereas HV was augmented by BAY K 8644. Methoxyverapamil (D600) in zero Ca<UP><SUB>o</SUB><SUP>2+</SUP></UP> did not affect HV in lamprey DA, nor did it prevent further constriction when Ca<UP><SUB>o</SUB><SUP>2+</SUP></UP> was restored during hypoxia in hagfish DA. Removal of extracellular sodium (Na<UP><SUB>o</SUB><SUP>+</SUP></UP>) caused a constriction in both species. Lamprey DA relaxed to prehypoxic tension following return to normoxia in zero Na<UP><SUB>o</SUB><SUP>+</SUP></UP>, whereas relaxation was inhibited in hagfish DA. Relaxation following HV was inhibited in lamprey DA when Na<UP><SUB>o</SUB><SUP>+</SUP></UP> and Ca<UP><SUB>o</SUB><SUP>2+</SUP></UP> were removed. These results show that HV is correlated with [Ca2+]c in lamprey DA and that Na+/Ca2+ exchange is used during HV in hagfish but not lamprey DA. Multiple receptor types appear to mediate stored intracellular calcium release in lamprey DA, and L-type calcium channels do not contribute significantly to constriction in either cyclostome.

vascular smooth muscle; hagfish; lamprey


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