| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, 2 Gene Experiment Center, Institute of Applied Biochemistry, and 3 Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-0006, Japan
Pressure overload,
such as hypertension, to the heart causes pathological cardiac
hypertrophy, whereas chronic exercise causes physiological cardiac
hypertrophy, which is defined as athletic heart. There are differences
in cardiac properties between these two types of hypertrophy. We
investigated whether mRNA expression of various cardiovascular
regulating factors differs in rat hearts that are physiologically and
pathologically hypertrophied, because we hypothesized that these two
types of cardiac hypertrophy induce different molecular phenotypes. We
used the spontaneously hypertensive rat (SHR group; 19 wk old) as a
model of pathological hypertrophy and swim-trained rats (trained group;
19 wk old, swim training for 15 wk) as a model of physiological
hypertrophy. We also used sedentary Wistar-Kyoto rats as the control
group (19 wk old). Left ventricular mass index for body weight was
significantly higher in SHR and trained groups than in the control
group. Expression of brain natriuretic peptide, angiotensin-converting
enzyme, and endothelin-1 mRNA in the heart was significantly higher in
the SHR group than in control and trained groups. Expression of
adrenomedullin mRNA in the heart was significantly lower in the trained
group than in control and SHR groups. Expression of
1-adrenergic receptor mRNA in the heart was
significantly higher in SHR and trained groups than in the control
group. Expression of 1-adrenergic receptor kinase mRNA,
which inhibits 1-adrenergic receptor activity, in the
heart was markedly higher in the SHR group than in control and trained
groups. We demonstrated for the first time that the manner of mRNA
expression of various cardiovascular regulating factors in the heart
differs between physiological and pathological cardiac hypertrophy.
cardiovascular regulating factor; athletic heart; spontaneously hypertensive rat; swim training; hypertension
This article has been cited by other articles:
|
|
 |
|
  H. Han, T. R. Hansen, B. Berg, B. W. Hess, and S. P. Ford Maternal undernutrition induces differential cardiac gene expression in pulmonary hypertensive steers at high elevation Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H382 - H389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Filho, A. J. Ferreira, S. H. S. Santos, S. R. S. Neves, E. R. Silva Camargos, L. K. Becker, H. A. Belchior, M. F. Dias-Peixoto, S. V. B. Pinheiro, and R. A. S. Santos Selective increase of angiotensin(1-7) and its receptor in hearts of spontaneously hypertensive rats subjected to physical training Exp Physiol, May 1, 2008; 93(5): 589 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Sato, M. Iemitsu, K. Aizawa, and R. Ajisaka Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle Am J Physiol Endocrinol Metab, May 1, 2008; 294(5): E961 - E968. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Aizawa, M. Iemitsu, T. Otsuki, S. Maeda, T. Miyauchi, and N. Mesaki Sex differences in steroidogenesis in skeletal muscle following a single bout of exercise in rats J Appl Physiol, January 1, 2008; 104(1): 67 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. L. Rocha, E. C. Carmo, F. R. Roque, N. Y. Hashimoto, L. V. Rossoni, C. Frimm, I. Aneas, C. E. Negrao, J. E. Krieger, and E. M. Oliveira Anabolic steroids induce cardiac renin-angiotensin system and impair the beneficial effects of aerobic training in rats Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3575 - H3583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Rankinen, T. Church, T. Rice, N. Markward, A. S. Leon, D. C. Rao, J. S. Skinner, S. N. Blair, and C. Bouchard Effect of Endothelin 1 Genotype on Blood Pressure Is Dependent on Physical Activity or Fitness Levels Hypertension, December 1, 2007; 50(6): 1120 - 1125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. W. Dorn II The Fuzzy Logic of Physiological Cardiac Hypertrophy Hypertension, May 1, 2007; 49(5): 962 - 970. [Full Text] [PDF]
|
|
|
|
|
|
K. Aizawa, M. Iemitsu, S. Maeda, S. Jesmin, T. Otsuki, C. N. Mowa, T. Miyauchi, and N. Mesaki Expression of steroidogenic enzymes and synthesis of sex steroid hormones from DHEA in skeletal muscle of rats Am J Physiol Endocrinol Metab, February 1, 2007; 292(2): E577 - E584. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sakamoto, T. Minamino, H. Toko, Y. Kayama, Y. Zou, M. Sano, E. Takaki, T. Aoyagi, K. Tojo, N. Tajima, et al. Upregulation of Heat Shock Transcription Factor 1 Plays a Critical Role in Adaptive Cardiac Hypertrophy Circ. Res., December 8, 2006; 99(12): 1411 - 1418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. S. Evangelista and J. E. Krieger Small gene effect and exercise training-induced cardiac hypertrophy in mice: an Ace gene dosage study Physiol Genomics, November 21, 2006; 27(3): 231 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Hilfiker-Kleiner, U. Landmesser, and H. Drexler Molecular Mechanisms in Heart Failure: Focus on Cardiac Hypertrophy, Inflammation, Angiogenesis, and Apoptosis J. Am. Coll. Cardiol., October 27, 2006; 48(9_Suppl_A): A56 - A66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Iemitsu, S. Maeda, S. Jesmin, T. Otsuki, Y. Kasuya, and T. Miyauchi Activation pattern of MAPK signaling in the hearts of trained and untrained rats following a single bout of exercise J Appl Physiol, July 1, 2006; 101(1): 151 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Iemitsu, S. Maeda, T. Otsuki, K. Goto, and T. Miyauchi Time course alterations of myocardial endothelin-1 production during the formation of exercise training-induced cardiac hypertrophy. Experimental Biology and Medicine, June 1, 2006; 231(6): 871 - 875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jesmin, S. Zaedi, S. Maeda, H. Togashi, I. Yamaguchi, K. Goto, and T. Miyauchi Endothelin Antagonism Suppresses Plasma and Cardiac Endothelin-1 Levels in SHRSPs at the Typical Hypertensive Stage. Experimental Biology and Medicine, June 1, 2006; 231(6): 919 - 924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-M. Lee, M.-S. Lin, T.-F. Chou, C.-H. Tsai, and N.-C. Chang Effect of pravastatin on development of left ventricular hypertrophy in spontaneously hypertensive rats Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H220 - H227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. W. Kong, N. Bodyak, P. Yue, Z. Liu, J. Brown, S. Izumo, and P. M. Kang Genetic expression profiles during physiological and pathological cardiac hypertrophy and heart failure in rats Physiol Genomics, March 21, 2005; 21(1): 34 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hashimoto, N. Kambara, R. Nohara, M. Yazawa, and S. Taguchi Expression of MHC-{beta} and MCT1 in cardiac muscle after exercise training in myocardial-infarcted rats J Appl Physiol, September 1, 2004; 97(3): 843 - 851. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. McMullen, T. Shioi, L. Zhang, O. Tarnavski, M. C. Sherwood, A. L. Dorfman, S. Longnus, M. Pende, K. A. Martin, J. Blenis, et al. Deletion of Ribosomal S6 Kinases Does Not Attenuate Pathological, Physiological, or Insulin-Like Growth Factor 1 Receptor-Phosphoinositide 3-Kinase-Induced Cardiac Hypertrophy Mol. Cell. Biol., July 15, 2004; 24(14): 6231 - 6240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Kang, P. Yue, Z. Liu, O. Tarnavski, N. Bodyak, and S. Izumo Alterations in apoptosis regulatory factors during hypertrophy and heart failure Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H72 - H80. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Iemitsu, T. Miyauchi, S. Maeda, T. Tanabe, M. Takanashi, M. Matsuda, and I. Yamaguchi Exercise training improves cardiac function-related gene levels through thyroid hormone receptor signaling in aged rats Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1696 - H1705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Frey, H. A. Katus, E. N. Olson, and J. A. Hill Hypertrophy of the Heart: A New Therapeutic Target? Circulation, April 6, 2004; 109(13): 1580 - 1589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Granger Endothelin Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2003; 285(2): R298 - R301. [Full Text] [PDF]
|
|
|
|
|
|
L. Moser, J. Faulhaber, R. J. Wiesner, and H. Ehmke Predominant activation of endothelin-dependent cardiac hypertrophy by norepinephrine in rat left ventricle Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1389 - R1394. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
