AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 282: R10-R18, 2002;
0363-6119/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shade, R. E.
Right arrow Articles by Denton, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shade, R. E.
Right arrow Articles by Denton, D. A.
Vol. 282, Issue 1, R10-R18, January 2002

Ingestive responses to administration of stress hormones in baboons

R. E. Shade1, J. R. Blair-West1,2, K. D. Carey1,3, L. J. Madden1, R. S. Weisinger4, J. E. Rivier5, W. W. Vale5, and D. A. Denton1,4

1 Department of Physiology and Medicine and 3 Southwest Regional Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245-0549; 2 Department of Physiology and 4 Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Melbourne, Victoria 3010, Australia; and 5 The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037

Experimental stress and the administration of the stress hormone ACTH have been reported to stimulate sodium appetite in many nonprimate species. Experiments were conducted to determine whether prolonged intracerebroventricular infusions of the neuropeptides corticotropin-releasing factor (CRF) and urocortin (Ucn), or systemic administration of ACTH, affected ingestive behaviors in a nonhuman primate, the baboon. Intracerebroventricular infusions of CRF or Ucn significantly decreased daily food intake. The decrease with Ucn continued into the postinfusion period. These infusions did not alter daily water intake. Daily voluntary intake of 300 mM NaCl solution was not increased, and there was evidence of reductions on days 2-4 of the infusions. Intramuscular injections of porcine ACTH or synthetic ACTH (Synacthen) for 5 days did not affect daily NaCl intake, although the doses were sufficient to increase cortisol secretion and arterial blood pressure. Sodium depletion by 3 days of furosemide injections did induce a characteristic sodium appetite in the same baboons. These results demonstrate the anorexigenic action of CRF and Ucn in this primate. Also, CRF, Ucn, and ACTH did not stimulate sodium appetite at the doses used.

food intake; sodium appetite; corticotropin-releasing factor; urocortin; adrenocorticotropic hormone; sodium deficiency


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. M. McBride and F. W. Flynn
Centrally administered vasopressin cross-sensitizes rats to amphetamine and drinking hypertonic NaCl
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1452 - R1458.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
W. A. Cupples
Peptides that regulate food intake
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1370 - R1374.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. E. Shade, J. R. Blair-West, K. D. Carey, L. J. Madden, R. S. Weisinger, and D. A. Denton
Synergy between angiotensin and aldosterone in evoking sodium appetite in baboons
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2002; 283(5): R1070 - R1078.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online