| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Renal and Urology Research, GlaxoSmithKline, King of Prussia, Pennsylania 19406
The renal microvasculature is an important component in the regulation of kidney function. Recent studies suggest that oxygen radicals can contribute to the modulation of renal cortical and medullary microvascular function under normal conditions as well as in pathophysiological conditions such as diabetes mellitus and hypertension. This review focuses on studies that indicate oxygen radicals can cause renal vasoconstriction, mediate the vasoconstriction of other agonists, and modulate nitric oxide-dependent actions in the normal kidney. Hypertension and diabetes mellitus are associated with oxidative stress. Recent investigations suggest that oxygen radicals may contribute to the enhanced renal vascular tone, increased sensitivity to vasoconstrictors, impaired endothelium-dependent vasodilation, and enhanced tubuloglomerular feedback found in these pathophysiological conditions.
nitric oxide; hypertension; diabetes; kidney; vasoconstriction; superoxide; antioxidants
This article has been cited by other articles:
|
|
 |
|
  I. Rubinstein, Z. Abassi, F. Milman, E. Ovcharenko, R. Coleman, J. Winaver, and O. S. Better Hyperbaric oxygen treatment improves GFR in rats with ischaemia/reperfusion renal injury: a possible role for the antioxidant/oxidant balance in the ischaemic kidney Nephrol. Dial. Transplant., September 17, 2008; (2008) gfn511v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Efrati, S. Berman, G. B. Aharon, Y. Siman-Tov, Z. Averbukh, and J. Weissgarten Application of normobaric hyperoxia therapy for amelioration of haemorrhagic shock-induced acute renal failure Nephrol. Dial. Transplant., July 1, 2008; 23(7): 2213 - 2222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Yu, H.-F. Bao, J. L. Self, D. C. Eaton, and M. N. Helms Aldosterone-induced increases in superoxide production counters nitric oxide inhibition of epithelial Na channel activity in A6 distal nephron cells Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1666 - F1677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Meier, J. Rossert, P.-F. Plouin, and M. Burnier Atherosclerotic renovascular disease: beyond the renal artery stenosis Nephrol. Dial. Transplant., April 1, 2007; 22(4): 1002 - 1006. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Just, A. J. M. Olson, C. L. Whitten, and W. J. Arendshorst Superoxide mediates acute renal vasoconstriction produced by angiotensin II and catecholamines by a mechanism independent of nitric oxide Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H83 - H92. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, A. F. Chen, and D. H. Wang Enhanced oxidative stress in kidneys of salt-sensitive hypertension: role of sensory nerves Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H3136 - H3143. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Palm, D. G. Buerk, P.-O. Carlsson, P. Hansell, and P. Liss Reduced Nitric Oxide Concentration in the Renal Cortex of Streptozotocin-Induced Diabetic Rats: Effects on Renal Oxygenation and Microcirculation Diabetes, November 1, 2005; 54(11): 3282 - 3287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Fellner and W. J. Arendshorst Angiotensin II, reactive oxygen species, and Ca2+ signaling in afferent arterioles Am J Physiol Renal Physiol, November 1, 2005; 289(5): F1012 - F1019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Wilcox Oxidative stress and nitric oxide deficiency in the kidney: a critical link to hypertension? Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R913 - R935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sharma, A. Cook, M. Smith, C. Valancius, and E. W. Inscho TGF-{beta} impairs renal autoregulation via generation of ROS Am J Physiol Renal Physiol, May 1, 2005; 288(5): F1069 - F1077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Wilcox and D. Gutterman Focus on oxidative stress in the cardiovascular and renal systems Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H3 - H6. [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhang, K. Rhinehart, G. Solis, J. Pittner, W. Lee-Kwon, W. J. Welch, C. S. Wilcox, and T. L. Pallone Chronic ANG II infusion increases NO generation by rat descending vasa recta Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H29 - H36. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Adler and H. Huang Oxidant stress in kidneys of spontaneously hypertensive rats involves both oxidase overexpression and loss of extracellular superoxide dismutase Am J Physiol Renal Physiol, November 1, 2004; 287(5): F907 - F913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhang, K. Rhinehart, W. Kwon, E. Weinman, and T. L. Pallone ANG II signaling in vasa recta pericytes by PKC and reactive oxygen species Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H773 - H781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Chade, J. D. Krier, M. Rodriguez-Porcel, J. F. Breen, M. A. McKusick, A. Lerman, and L. O. Lerman Comparison of acute and chronic antioxidant interventions in experimental renovascular disease Am J Physiol Renal Physiol, June 1, 2004; 286(6): F1079 - F1086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Rodriguez-Iturbe, N. D. Vaziri, J. Herrera-Acosta, and R. J. Johnson Oxidative stress, renal infiltration of immune cells, and salt-sensitive hypertension: all for one and one for all Am J Physiol Renal Physiol, April 1, 2004; 286(4): F606 - F616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Z. Haque and D. S. A. Majid Assessment of Renal Functional Phenotype in Mice Lacking gp91PHOX Subunit of NAD(P)H Oxidase Hypertension, February 1, 2004; 43(2): 335 - 340. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Rodrigo, W. Passalacqua, J. Araya, M. Orellana, and G. Rivera Homocysteine and Essential Hypertension J. Clin. Pharmacol., December 1, 2003; 43(12): 1299 - 1306. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-P. Tzeng, R.-S. Yang, T.-H. Ueng, S.-Y. Lin-Shiau, and S.-H. Liu Motorcycle Exhaust Particulates Enhance Vasoconstriction in Organ Culture of Rat Aortas and Involve Reactive Oxygen Species Toxicol. Sci., September 1, 2003; 75(1): 66 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Lassegue and R. E. Clempus Vascular NAD(P)H oxidases: specific features, expression, and regulation Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2003; 285(2): R277 - R297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Komers and S. Anderson Paradoxes of nitric oxide in the diabetic kidney Am J Physiol Renal Physiol, June 1, 2003; 284(6): F1121 - F1137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Persson The kidney and hypertension Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2003; 284(5): R1176 - R1178. [Full Text] [PDF]
|
|
|
|
|
|
M. Nava, Y. Quiroz, N. Vaziri, and B. Rodriguez-Iturbe Melatonin reduces renal interstitial inflammation and improves hypertension in spontaneously hypertensive rats Am J Physiol Renal Physiol, March 1, 2003; 284(3): F447 - F454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Alvarez, Y. Quiroz, M. Nava, H. Pons, and B. Rodriguez-Iturbe Overload proteinuria is followed by salt-sensitive hypertension caused by renal infiltration of immune cells Am J Physiol Renal Physiol, November 1, 2002; 283(5): F1132 - F1141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Krier, M. Rodriguez-Porcel, P. J. M. Best, J. C. Romero, A. Lerman, and L. O. Lerman Vascular responses in vivo to 8-epi PGF2alpha in normal and hypercholesterolemic pigs Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R303 - R308. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
