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Am J Physiol Regul Integr Comp Physiol 282: R509-R518, 2002; doi:10.1152/ajpregu.00509.2001
0363-6119/02 $5.00
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Vol. 282, Issue 2, R509-R518, February 2002

Expression and binding activity of the glucocorticoid receptor are upregulated in septic muscle

Xiaoyan Sun, David R. Fischer, Timothy A. Pritts, Curtis J. Wray, and Per-Olof Hasselgren

Department of Surgery, University of Cincinnati, and Shriners Hospitals for Children, Cincinnati, Ohio 45267

We examined the influence of sepsis, induced by cecal ligation and puncture in rats, on the protein and gene expression and hormone binding activity of the glucocorticoid receptor (GR) in skeletal muscle. Sepsis resulted in increased GR mRNA and protein levels and upregulated hormone binding activity in extensor digitorum longus and soleus muscles. Scatchard analysis suggested that the increased GR hormone binding activity reflected an increased number of hormone binding sites, whereas receptor affinity for glucocorticoids was unchanged. The GR antagonist RU-38486 blocked the sepsis-induced increase in GR expression and hormone binding activity, implicating a positive regulatory effect of glucocorticoids on GR expression and binding activity under the present experimental conditions. The results suggest that glucocorticoid-dependent metabolic changes in skeletal muscle during sepsis may reflect not only high circulating glucocorticoid levels but increased amounts and hormone binding activity of the GR as well.

muscle cachexia; injury; cancer; infection


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