AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 282: R528-R536, 2002; doi:10.1152/ajpregu.00085.2001
0363-6119/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (10)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kritsch, K. R.
Right arrow Articles by Ney, D. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kritsch, K. R.
Right arrow Articles by Ney, D. M.
Vol. 282, Issue 2, R528-R536, February 2002

Dexamethasone decreases serum and liver IGF-I and maintains liver IGF-I mRNA in parenterally fed rats

K. R. Kritsch1, S. Murali1, M. L. Adamo2, and D. M. Ney1

1 Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706; and 2 Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78224

Insulin-like growth factor-I (IGF-I) gene expression is regulated by nutritional and hormonal factors. High-dose glucocorticoids decrease food intake, and this confounds studies addressing glucocorticoid effects on IGF-I gene regulation. We investigated alterations in the hepatic IGF-I endocrine system induced by a catabolic dose of dexamethasone (Dex) in rats given adequate nutrition by continuous infusion of total parenteral nutrition (TPN) solution with or without IGF-I administration. The four TPN groups included control, +Dex, +IGF-I, and +IGF-I + Dex (n = 9-11/group). Dex induced a 12% loss of body weight in association with a 50% decrease in hepatic immunoreactive IGF-I, a 10% decrease in serum IGF-I, and no change in steady-state liver IGF-I mRNA or growth hormone (GH) receptor binding. Exogenous IGF-I increased serum IGF-I, attenuated Dex-induced catabolism, and did not reduce hepatic levels of IGF-I and IGF-I mRNA despite decreased serum GH. These data suggest that Dex-induced catabolism is associated with downregulation of the hepatic IGF-I endocrine system at the translational or posttranslational level when adequate nutrition is provided.

glucocorticoids; growth hormone; insulin-like growth factor-I, insulin-like growth factor-I binding proteins


This article has been cited by other articles:


Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Ayaori, S. Sawada, A. Yonemura, N. Iwamoto, M. Ogura, N. Tanaka, K. Nakaya, M. Kusuhara, H. Nakamura, and F. Ohsuzu
Glucocorticoid Receptor Regulates ATP-Binding Cassette Transporter-A1 Expression and Apolipoprotein-Mediated Cholesterol Efflux From Macrophages
Arterioscler. Thromb. Vasc. Biol., January 1, 2006; 26(1): 163 - 168.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
E. M. Dahly, M. E. Miller, P. K. Lund, and D. M. Ney
Postreceptor Resistance to Exogenous Growth Hormone Exists in the Jejunal Mucosa of Parenterally Fed Rats
J. Nutr., March 1, 2004; 134(3): 530 - 537.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Fournier, Z.-S. Huang, H. Li, X. Da, B. Cercek, and M. I. Lewis
Insulin-like growth factor I prevents corticosteroid-induced diaphragm muscle atrophy in emphysematous hamsters
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2003; 285(1): R34 - R43.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. B. Gillingham, E. M. Dahly, S. G. Murali, and D. M. Ney
IGF-I treatment facilitates transition from parenteral to enteral nutrition in rats with short bowel syndrome
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R363 - R371.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online