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Am J Physiol Regul Integr Comp Physiol 282: R623-R626, 2002; doi:10.1152/ajpregu.00310.2001
0363-6119/02 $5.00
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Vol. 282, Issue 2, R623-R626, February 2002

RAPID COMMUNICATION
Enhanced gene expression of endothelial nitric oxide synthase in brown adipose tissue during cold exposure

Kazue Kikuchi-Utsumi, Bihu Gao, Hiroshi Ohinata, Masaaki Hashimoto, Noriyuki Yamamoto, and Akihiro Kuroshima

Department of Physiology 1, Asahikawa Medical University School of Medicine, Asahikawa 078 - 8510, Japan

It has been shown that norepinephrine (NE) can mediate vasodilatation by stimulating the production of nitric oxide (NO) in brown adipose tissue (BAT), resulting in an increase in BAT blood flow. We speculated that constitutive NO synthase (NOS) is involved in this NO production. However, it is not known whether constitutive NOS is expressed in BAT. To answer this question, we assessed the expression of two types of constitutive NOS, endothelial (eNOS) and neuronal NOS (nNOS), in BAT of rats. eNOS was abundantly expressed in both BAT and isolated brown adipocytes, whereas nNOS was not. Cold exposure, which is known to stimulate NE release from sympathetic nerve terminals in BAT, led to a significant increase in eNOS mRNA in this tissue. In contrast, very low levels of inducible NOS (iNOS) mRNA were expressed, and cold stimulation failed to increase iNOS mRNA levels in BAT. These results suggest that eNOS is the primary isoform that is responsible for NO production in BAT and that its expression may be under sympathetic control.

inducible nitric oxide synthase


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