AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 282: R738-R743, 2002; doi:10.1152/ajpregu.00263.2001
0363-6119/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (6)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Barfull, A.
Right arrow Articles by Planas, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barfull, A.
Right arrow Articles by Planas, J. M.
Vol. 282, Issue 3, R738-R743, March 2002

Regulation of SGLT1 expression in response to Na+ intake

Anna Barfull1, Carles Garriga1, Albert Tauler2, and Joana M. Planas1

1 Departament de Fisiologia-Divisió IV, 2 Departament de Bioquímica i Biologia Molecular-Divisió IV, Facultat de Farmàcia, Universitat de Barcelona, E-08028 Barcelona, Spain

In the chicken intestine, the reduction in Na+ intake led to a decrease in the transport of alpha -methyl-D-glucoside in the ileum (reduction of 42%) and in the rectum (51%). These reductions were reversed within 24 h after resalination and were inversely correlated to the changes in aldosterone plasma concentration. The reduction in intestinal hexose transport in the low Na+-fed animals was due to a decrease in the number of Na+-dependent D-glucose cotransporters (SGLT1) in the rectum (46%) and in the ileum (38%). Northern blot analysis showed that specific SGLT1 mRNA was expressed in the jejunum, ileum, and rectum. The amount of SGLT1 mRNA was the same in all intestinal regions and was not affected by Na+ intake, supporting the view that the effects of dietary Na+ on intestinal hexose transport involve posttranscriptional regulation of SGLT1. This study suggests that changes in SGLT1 expression may be involved in the homeostasis of Na+.

intestine; sugar transport; Northern blot; Western blot


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. Miro-Queralt, J. J. Guinovart, and J. M. Planas
Sodium tungstate decreases sucrase and Na+/D-glucose cotransporter in the jejunum of diabetic rats
Am J Physiol Gastrointest Liver Physiol, September 1, 2008; 295(3): G479 - G484.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Mate, A. Barfull, A. M. Hermosa, L. Gomez-Amores, C. M. Vazquez, and J. M. Planas
Regulation of sodium-glucose cotransporter SGLT1 in the intestine of hypertensive rats
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R760 - R767.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online