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Am J Physiol Regul Integr Comp Physiol 282: R850-R857, 2002; doi:10.1152/ajpregu.00297.2001
0363-6119/02 $5.00
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Vol. 282, Issue 3, R850-R857, March 2002

Role of spinal NMDA and non-NMDA receptors in the pressor reflex response to abdominal ischemia

B. Y. Gee, S. C. Tjen-A-Looi, J. M. Hill, P. S. Chahal, and J. C. Longhurst

Department of Medicine, University of California, Irvine, California 92697-4075

Abdominal ischemia induces a pressor reflex caused mainly by C-fiber afferent stimulation. Because excitatory amino acids, such as glutamate, bind to N-methyl-D-aspartate (NMDA) and non-NMDA [dl-alpha -amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)] receptors and serve as important spinal neurotransmitters, we hypothesized that both receptors play a role in the abdominal ischemia pressor reflex. In chloralose-anesthetized cats, NMDA receptor blockade with 25.0 mM dl-2-amino-5-phosphonopentanoate did not alter the pressor reflex (33 ± 9 to 33 ± 7 mmHg, P > 0.05, n = 4), whereas AMPA receptor blockade with 4.0 mM 6-nitro-7-sulfamylbenzo(f)quinoxaline-2,3-dione significantly attenuated the reflex (29 ± 5 to 16 ± 4 mmHg, P < 0.05, n = 6). Because several studies suggest that anesthesia masks the effects of glutamatergic receptors, this experiment was repeated on decerebrate cats, and in this group, NMDA receptor blockade with 25.0 mM dl-2-amino-5-phosphonopentanoate significantly altered the pressor reflex (36 ± 3 to 25 ± 4 mmHg, P < 0.05, n = 5). Our combined data suggest that spinal NMDA and AMPA receptors play a role in the abdominal ischemia pressor reflex.

6-nitro-7-sulfamylbenzo(f)quinoxaline-2,3-dione; dl-2-amino-5-phosphonopentanoate; alpha -chloralose; decerebrate


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