AJP - Regu Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 282: R890-R899, 2002. First published November 8, 2001; doi:10.1152/ajpregu.0527.2001
0363-6119/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
282/3/R890    most recent
0527.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (17)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tang, H.
Right arrow Articles by Gallagher, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tang, H.
Right arrow Articles by Gallagher, D.
Vol. 282, Issue 3, R890-R899, March 2002

High-resolution magnetic resonance imaging tracks changes in organ and tissue mass in obese and aging rats

Haiying Tang1,2, Joseph R. Vasselli1, Ed X. Wu2, Carol N. Boozer1, and Dympna Gallagher1

1 Obesity Research Center, St. Luke's-Roosevelt Hospital, New York 10025; and 2 Department of Radiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032

Magnetic resonance imaging (MRI) has the ability to discriminate between various soft tissues in vivo. Whole body, specific organ, total adipose tissue (TAT), intra-abdominal adipose tissue (IAAT), and skeletal muscle (SM) weights determined by MRI were compared with weights determined by dissection and chemical analysis in two studies with male Sprague-Dawley rats. A 4.2-T MRI machine acquired high-resolution, in vivo, longitudinal whole body images of rats as they developed obesity or aged. Weights of the whole body and specific tissues were determined using computer image analysis software, including semiautomatic segmentation algorithms for volume calculations. High correlations were found for body weight (r = 0.98), TAT (r = 0.99), and IAAT (r = 0.98) between MRI and dissection and chemical analyses. MRI estimated the weight of the brain, kidneys, and spleen with high accuracy (r > 0.9), but overestimated IAAT, SM, and liver volumes. No differences were detected in organ weights using MRI and dissection measurements. Longitudinal MRI measurements made during the development of obesity and aging accurately represented changes in organ and tissue mass.

longitudinal body composition; in vivo; obesity; high-fat diet; small animal


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Brennick, A. I. Pack, K. Ko, E. Kim, S. Pickup, G. Maislin, and R. J. Schwab
Altered Upper Airway and Soft Tissue Structures in the New Zealand Obese Mouse
Am. J. Respir. Crit. Care Med., January 15, 2009; 179(2): 158 - 169.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
Z. Chen, Z. Wang, T. Lohman, S. B. Heymsfield, E. Outwater, J. S. Nicholas, T. Bassford, A. LaCroix, D. Sherrill, M. Punyanitya, et al.
Dual-Energy X-Ray Absorptiometry Is a Valid Tool for Assessing Skeletal Muscle Mass in Older Women
J. Nutr., December 1, 2007; 137(12): 2775 - 2780.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
X. Y. Ruan, D. Gallagher, T. Harris, J. Albu, S. Heymsfield, P. Kuznia, and S. Heshka
Estimating whole body intermuscular adipose tissue from single cross-sectional magnetic resonance images
J Appl Physiol, February 1, 2007; 102(2): 748 - 754.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. C. Garcia, I. Wernstedt, A. Berndtsson, M. Enge, M. Bell, O. Hultgren, M. Horn, B. Ahren, S. Enerback, C. Ohlsson, et al.
Mature-onset obesity in interleukin-1 receptor I knockout mice.
Diabetes, May 1, 2006; 55(5): 1205 - 1213.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
H. Xie, C. Audette, M. Hoffee, J. M. Lambert, and W. A. Blattler
Pharmacokinetics and Biodistribution of the Antitumor Immunoconjugate, Cantuzumab Mertansine (huC242-DM1), and Its Two Components in Mice
J. Pharmacol. Exp. Ther., March 1, 2004; 308(3): 1073 - 1082.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
G. W. Cline, K. Johnson, W. Regittnig, P. Perret, E. Tozzo, L. Xiao, C. Damico, and G. I. Shulman
Effects of a Novel Glycogen Synthase Kinase-3 Inhibitor on Insulin-Stimulated Glucose Metabolism in Zucker Diabetic Fatty (fa/fa) Rats
Diabetes, October 1, 2002; 51(10): 2903 - 2910.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. D. Bentley, M. C. Ortiz, E. L. Ritman, and J. C. Romero
The use of microcomputed tomography to study microvasculature in small rodents
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1267 - R1279.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online