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Am J Physiol Regul Integr Comp Physiol 282: R1210-R1218, 2002; doi:10.1152/ajpregu.00248.2001
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Vol. 282, Issue 4, R1210-R1218, April 2002

Brief food restriction increases FA oxidation and glycogen synthesis under insulin-stimulated conditions

Michelle Z. Tucker and Lorraine P. Turcotte

Department of Kinesiology and University of Southern California Diabetes Research Center, University of Southern California, Los Angeles, California 90089

To determine the effects of brief food restriction on fatty acid (FA) metabolism, hindlimbs of F344/BN rats fed either ad libitum (AL) or food restricted (FR) to 60% of baseline food intake for 28 days were perfused under hyperglycemic-hyperinsulinemic conditions (20 mM glucose, 1 mM palmitate, 1,000 µU/ml insulin, [3-3H]glucose, and [1-14C]palmitate). Basal glucose and insulin levels were significantly lower (P < 0.05) in FR vs. AL rats. Palmitate uptake (34.3 ± 2.7 vs. 24.5 ± 3.1 nmol/g/min) and oxidation (3.8 ± 0.2 vs. 2.7 ± 0.3 nmol · g-1 · min-1) were significantly higher (P < 0.05) in FR vs. AL rats, respectively. Glucose uptake was increased in FR rats and was accompanied by significant increases in red and white gastrocnemius glycogen synthesis, indicating an improvement in insulin sensitivity. Although muscle triglyceride (TG) levels were not significantly different between groups, glucose uptake and total preperfusion TG concentration were negatively correlated (r2 = 0.27, P < 0.05). In conclusion, our results show that under hyperglycemic-hyperinsulinemic conditions, brief FR resulted in an increase in FA oxidative disposal that may contribute to the improvement in insulin sensitivity.

food restriction; fatty acid uptake; intramuscular triglycerides; insulin sensitivity; skeletal muscle


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