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Am J Physiol Regul Integr Comp Physiol 282: R979-R984, 2002. First published November 29, 2001; doi:10.1152/ajpregu.00520.2001
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Vol. 282, Issue 4, R979-R984, April 2002

Cytokine-mediated downregulation of vasopressin V1A receptors during acute endotoxemia in rats

Michael Bucher1, Jonny Hobbhahn1, Kai Taeger1, and Armin Kurtz2

Departments of 1 Anesthesiology and 2 Physiology, University of Regensburg, 93042 Regensburg, Germany

The reduced pressure response to vasopressin during acute sepsis has directed our interest to the regulation of vasopressin V1A receptors. Rats were injected with lipopolysaccharide for induction of experimental gram-negative sepsis. V1A receptor gene expression was downregulated in the liver, lung, kidney, and heart during endotoxemia. Inasmuch as the concentrations of proinflammatory cytokines such as interleukin-1beta , tumor necrosis factor-alpha , and interferon-gamma were highly increased during sepsis, the influence of these cytokines on V1A receptor expression was investigated in primary cultures of hepatocytes and in the aortic vascular smooth muscle cell line A7r5. V1A receptor expression was downregulated by the cytokines in a nitric oxide-independent manner. Blood pressure dose-response studies after injection of endotoxin showed a diminished responsiveness to the selective V1 receptor agonist Phe2,Ile3,Orn8-vasopressin. Our data show that sepsis causes a downregulation of V1A receptors and suggest that this effect is likely mediated by proinflammatory cytokines. We propose that this downregulation of V1A receptors contributes to the attenuated responsiveness of blood pressure in response to vasopressin and, therefore, contributes to the circulatory failure in septic shock.

blood pressure; hepatocytes; vascular smooth muscle; A7r5 cell line; nitric oxide


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