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Veterans Administration Medical Center, Omaha 68105; and Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178
We previously demonstrated
that amylin inhibits food intake and gastric emptying in rats with
half-maximal effective doses (ED50s) of 8 and 3 pmol · kg
1 · min1 and
maximal inhibitions of 78 and 60%, respectively. In this study of
identical design, rats received intravenous infusions of salmon
calcitonin (sCT), rat calcitonin (rCT), rat calcitonin gene-related
peptide (rCGRP), and rat adrenomedullin (rADM) for 3 h at dark
onset, and food intake was measured for 17 h or for 15 min and
gastric emptying of saline was measured during the final 5 min. sCT,
rCGRP, and rADM inhibited food intake with estimated ED50s
of 0.5, 26, and 35 pmol · kg1 · min1 and
maximal inhibitions of 88, 90, and 49%, respectively. rCT was not
effective at doses up to 100 pmol · kg1 · min1. sCT,
rCGRP, rADM, and rCT inhibited gastric emptying with ED50s of 1, 130, 160, and 730 pmol · kg1 · min1 and
maximal inhibitions of 60, 66, 60, and 33%, respectively. These
results suggest that amylin and sCT may act by a common mechanism to
decrease food intake, which includes inhibition of gastric emptying.
calcitonin; calcitonin gene-related peptide; adrenomedullin; anorexia; potency
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