AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 282: R1422-R1428, 2002; doi:10.1152/ajpregu.00805.2000
0363-6119/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by D'Arbe, M.
Right arrow Articles by Lavidis, N. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by D'Arbe, M.
Right arrow Articles by Lavidis, N. A.
Vol. 282, Issue 5, R1422-R1428, May 2002

Stressful animal housing conditions and their potential effect on sympathetic neurotransmission in mice

M. D'Arbe1, R. Einstein2, and N. A. Lavidis1

1 The Department of Physiology and Pharmacology, The School of Biomedical Sciences, The University of Queensland, St. Lucia, Brisbane, Queensland 4072; and 2 The Department of Pharmacology, The University of Sydney, Sydney, New South Wales 2006, Australia

Although the sympathetic nervous system (SNS) plays a major role in mediating the peripheral stress response, due consideration is not usually given to the effects of prolonged stress on the SNS. The present study examined changes in neurotransmission in the SNS after exposure of mice (BALB/c) to stressful housing conditions. Focal extracellular recording of excitatory junction currents (EJCs) was used as a relative measure of neurotransmitter release from different regions of large surface areas of the mouse vas deferens. Mice were either group housed (control), isolation housed (social deprivation), group housed in a room containing rats (rat odor stress), or isolation housed in a room containing rats (concurrent stress). Social deprivation and concurrent stressors induced an increase of 30 and 335% in EJC amplitude, respectively. The success rate of recording EJCs from sets of varicosities in the concurrent stressor group was greater compared with all other groups. The present study has shown that some common animal housing conditions act as stressors and induce significant changes in sympathetic neurotransmission.

stressor; varicosities; social isolation; novel odor; vas deferens


This article has been cited by other articles:


Home page
 J. Physiol.Home page
S.-E. Genest, R. Gulemetova, S. Laforest, G. Drolet, and R. Kinkead
Neonatal maternal separation and sex-specific plasticity of the hypoxic ventilatory response in awake rat
J. Physiol., January 15, 2004; 554(2): 543 - 557.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Ehmke
Mouse gene targeting in cardiovascular physiology
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R28 - R30.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online