| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Animal Science, Cornell University, Ithaca, New York 14853
To better understand the biology of leptin during prenatal life, the developmental and spatial regulation of leptin was studied in ovine fetuses. Fetal plasma leptin increased steadily between days 40 and 143 postcoitus (PC), but it was unrelated to fetal weight or placental weight at day 135 PC. Leptin gene expression was detected in fetal brain and liver during most of gestation and in fetal adipose tissue after day 100 PC. At day 130 PC, expression in fetal perirenal adipose tissue was ~10% of maternal expression. In contrast, leptin gene expression was never detected in the placenta and other uteroplacental tissues. When ewes were fed 55% of requirements between days 122 and 135 PC, fetal plasma leptin remained constant despite acute reduction in maternal concentration. We conclude that fetal plasma leptin originates mostly from nonadipose tissue in early pregnancy and, in addition, from fetal adipose tissue near term. The role of fetal plasma leptin remains uncertain given the lack of nutritional regulation and association with fetal growth.
pregnancy; placenta; nutrition
This article has been cited by other articles:
|
|
 |
|
  A. J. Forhead and A. L. Fowden The hungry fetus? Role of leptin as a nutritional signal before birth J. Physiol., March 15, 2009; 587(6): 1145 - 1152. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. E. Schlabritz-Loutsevitch, J. C. Lopez-Alvarenga, A. G. Comuzzie, M. M. Miller, S. P. Ford, C. Li, G. B. Hubbard, R. J. Ferry Jr, and P. W. Nathanielsz The Prolonged Effect of Repeated Maternal Glucocorticoid Exposure on the Maternal and Fetal Leptin/Insulin-like Growth Factor Axis in Papio species Reproductive Sciences, March 1, 2009; 16(3): 308 - 319. [Abstract] [PDF]
|
|
|
|
 |
|
 J. A. Duffield, T. Vuocolo, R. Tellam, B. S. Yuen, B. S. Muhlhausler, and I. C. McMillen Placental restriction of fetal growth decreases IGF1 and leptin mRNA expression in the perirenal adipose tissue of late gestation fetal sheep Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1413 - R1419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Ducsay, K. Hyatt, M. Mlynarczyk, K. M. Kaushal, and D. A. Myers Long-term hypoxia increases leptin receptors and plasma leptin concentrations in the late-gestation ovine fetus Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1406 - R1413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. C. McMillen, C. L. Adam, and B. S. Muhlhausler Early origins of obesity: programming the appetite regulatory system J. Physiol., May 15, 2005; 565(1): 9 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. C. Mcmillen and J. S. Robinson Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming Physiol Rev, April 1, 2005; 85(2): 571 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Edwards, J. R. McFarlane, K. G. Kauter, and I. C. McMillen Impact of periconceptional nutrition on maternal and fetal leptin and fetal adiposity in singleton and twin pregnancies Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R39 - R45. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Ravelich, A. N. Shelling, A. Ramachandran, S. Reddy, J. A. Keelan, D. N. Wells, A. J. Peterson, R. S.F. Lee, and B. H. Breier Altered Placental Lactogen and Leptin Expression in Placentomes from Bovine Nuclear Transfer Pregnancies Biol Reprod, December 1, 2004; 71(6): 1862 - 1869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.S.J. Yuen, P.C. Owens, M.E. Symonds, D.H. Keisler, J.R. McFarlane, K.G. Kauter, and I.C. McMillen Effects of Leptin on Fetal Plasma Adrenocorticotropic Hormone and Cortisol Concentrations and the Timing of Parturition in the Sheep Biol Reprod, June 1, 2004; 70(6): 1650 - 1657. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Ehrhardt, P. L. Greenwood, A. W. Bell, and Y. R. Boisclair Plasma Leptin Is Regulated Predominantly by Nutrition in Preruminant Lambs J. Nutr., December 1, 2003; 133(12): 4196 - 4201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Leury, L. H. Baumgard, S. S. Block, N. Segoale, R. A. Ehrhardt, R. P. Rhoads, D. E. Bauman, A. W. Bell, and Y. R. Boisclair Effect of insulin and growth hormone on plasma leptin in periparturient dairy cows Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2003; 285(5): R1107 - R1115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhao, T. H. Kunz, N. Tumba, L. Clamon Schulz, C. Li, M. Reeves, and E. P. Widmaier Comparative analysis of expression and secretion of placental leptin in mammals Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2003; 285(2): R438 - R446. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
