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Am J Physiol Regul Integr Comp Physiol 282: R1746-R1753, 2002. First published February 21, 2002; doi:10.1152/ajpregu.00529.2001
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Vol. 282, Issue 6, R1746-R1753, June 2002

Baroreflex stabilization of the double (pressure-rate) product at 0.05 Hz in conscious rabbits

Bruce N. Van Vliet1, Francesca Belforti2, and Jean-Pierre Montani2

1 Faculty of Medicine, Division of Basic Medical Sciences, Memorial University of Newfoundland, St. John's, Newfoundland, Canada A1B 3V6; and 2 Institute of Physiology, University of Fribourg, CH-1700 Fribourg, Switzerland

The product of heart rate (HR) and systolic blood pressure (SBP), the double product (DP), is an indirect index of cardiac oxygen consumption. We used spectral analysis to test the hypothesis that baroreflex adjustments of HR stabilize the DP during spontaneous variations in SBP. SBP and HR were recorded by telemetry in five male conscious rabbits. HR and SBP power spectra each exhibited a low frequency peak at ~0.05 Hz that was associated with high (>0.5) spectral coherence and a positive phase relationship between SBP and HR (SBP leading). A prominent peak was absent in the spectra of their product, suggesting that SBP and HR interacted to reduce DP variability in this frequency region. In contrast, a prominent 0.05-Hz peak was present in the power spectrum of calculated surrogates of the DP in which reflex interactions between HR and SBP had been removed. Our results suggest that baroreflex adjustments of HR stabilize the DP during spontaneous low-frequency variations in SBP in conscious rabbits.

heart rate; systolic blood pressure


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