AJP - Regu Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 282: R1762-R1772, 2002. First published February 7, 2002; doi:10.1152/ajpregu.00766.2001
0363-6119/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow A corrigendum has been published
Right arrow All Versions of this Article:
282/6/R1762    most recent
00766.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (25)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ledeboer, A.
Right arrow Articles by Van Dam, A.-M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ledeboer, A.
Right arrow Articles by Van Dam, A.-M.
Vol. 282, Issue 6, R1762-R1772, June 2002

Site-specific modulation of LPS-induced fever and interleukin-1beta expression in rats by interleukin-10

Annemarie Ledeboer, Rob Binnekade, John J. P. Brevé, John G. J. M. Bol, Fred J. H. Tilders, and Anne-Marie Van Dam

Research Institute Neurosciences Free University, Department of Medical Pharmacology, VU University Medical Center, 1081 BT Amsterdam, The Netherlands

Bacterial lipopolysaccharide (LPS) induces fever that is mediated by pyrogenic cytokines such as interleukin (IL)-1beta . We hypothesized that the anti-inflammatory cytokine IL-10 modulates the febrile response to LPS by suppressing the production of pyrogenic cytokines. In rats, intravenous but not intracerebroventricular infusion of IL-10 was found to attenuate fever induced by peripheral administration of LPS (10 µg/kg iv). IL-10 also suppressed LPS-induced IL-1beta production in peripheral tissues and in the brain stem. In contrast, central administration of IL-10 attenuated the febrile response to central LPS (60 ng/rat icv) and decreased IL-1beta production in the hypothalamus and brain stem but not in peripheral tissues and plasma. Furthermore, intravenous LPS upregulated expression of IL-10 receptor (IL-10R1) mRNA in the liver, whereas intracerebroventricular LPS enhanced IL-10R1 mRNA in the hypothalamus. We conclude that IL-10 modulates the febrile response by acting in the periphery or in the brain dependent on the primary site of inflammation and that its mechanism of action most likely involves inhibition of local IL-1beta production.

inflammation; brain; thermoregulation; endotoxin; cytokine


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
S.-H. Yeh, J.-J. Hung, P.-W. Gean, and W.-C. Chang
Hypoxia-Inducible Factor-1{alpha} Protects Cultured Cortical Neurons from Lipopolysaccharide-Induced Cell Death via Regulation of NR1 Expression
J. Neurosci., December 24, 2008; 28(52): 14259 - 14270.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. S. Akarsu and S. Mamuk
Escherichia coli lipopolysaccharides produce serotype-specific hypothermic response in biotelemetered rats
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2007; 292(5): R1846 - R1850.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Divangahi, A. Demoule, G. Danialou, L. Yahiaoui, W. Bao, Z. Xing, and B. J. Petrof
Impact of IL-10 on Diaphragmatic Cytokine Expression and Contractility during Pseudomonas Infection
Am. J. Respir. Cell Mol. Biol., April 1, 2007; 36(4): 504 - 512.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Nickerson, G. F. Elphick, J. Campisi, B. N. Greenwood, and M. Fleshner
Physical activity alters the brain Hsp72 and IL-1{beta} responses to peripheral E. coli challenge
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2005; 289(6): R1665 - R1674.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. A. Romanovsky
Anorexia: the toll for lipopolysaccharide recognition
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R274 - R275.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. A. Romanovsky and S. R. Petersen
The spleen: another mystery about its function
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1378 - R1379.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Scholz
Fever
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R913 - R915.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Mouihate, M-S. Clerget-Froidevaux, K. Nakamura, M. Negishi, J. L. Wallace, and Q. J. Pittman
Suppression of fever at near term is associated with reduced COX-2 protein expression in rat hypothalamus
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2002; 283(3): R800 - R805.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online