AJP - Regu Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 283: R309-R319, 2002. First published March 29, 2002; doi:10.1152/ajpregu.00741.2001
0363-6119/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/2/R309    most recent
00741.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (27)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Frisbee, J. C.
Right arrow Articles by Lombard, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Frisbee, J. C.
Right arrow Articles by Lombard, J. H.
Vol. 283, Issue 2, R309-R319, August 2002

Integration of hypoxic dilation signaling pathways for skeletal muscle resistance arteries

Jefferson C. Frisbee1, Kristopher G. Maier1, John R. Falck2, Richard J. Roman1, and Julian H. Lombard1

1 Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226; and 2 Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390

Mediator contributions to hypoxic dilation of rat gracilis muscle resistance arteries were determined by measuring dilation, vascular smooth muscle hyperpolarization, and metabolite production after incremental hypoxia. Nitric oxide (NO) synthase inhibition abolished responses to mild hypoxia, whereas COX inhibition impaired responses to more severe hypoxia by 77%. Blocking 20-hydroxyeicosatetraenoic acid (20-HETE) impaired responses to moderate hypoxia. With only NO systems intact, responses were maintained with mild hypoxia (88% normal) mediated via KCa channels. When only COX pathways were intact, responses to moderate-severe hypoxia were largely retained (79% of normal) mediated via KATP channels. Vessel responses to moderate hypoxia were retained with only 20-HETE systems intact mediated via KCa channels. NO production increased 5.6-fold with mild hypoxia; greater hypoxia was without further effect. With increased hypoxia, 20-HETE levels fell to 40% of control values. 6-keto-PGF1alpha levels were not altered with mild hypoxia, but increased 4.6-fold with severe hypoxia. These results suggest vascular reactivity to progressive hypoxia represents an integration of NO production (mild hypoxia), PGI2 production (severe hypoxia), and reduced 20-HETE levels (moderate hypoxia).

nitric oxide; prostacyclin; skeletal muscle microcirculation; oxygen-induced vascular reactivity; cytochrome P-450 4a enzymes; microvessels; 20-hydroxyeicosatetraenoic acid


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. C. Frisbee, J. M. Hollander, R. W. Brock, H.-G. Yu, and M. A. Boegehold
Integration of skeletal muscle resistance arteriolar reactivity for perfusion responses in the metabolic syndrome
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2009; 296(6): R1771 - R1782.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. A. Stapleton, Adam. G. Goodwill, M. E. James, and J. C. Frisbee
Altered mechanisms of endothelium-dependent dilation in skeletal muscle arterioles with genetic hypercholesterolemia
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1110 - R1119.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
G. Zhao, A. Adebiyi, Q. Xi, and J. H. Jaggar
Hypoxia reduces KCa channel activity by inducing Ca2+ spark uncoupling in cerebral artery smooth muscle cells
Am J Physiol Cell Physiol, June 1, 2007; 292(6): C2122 - C2128.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Toth, M. Pal, M. Intaglietta, and P. C. Johnson
Contribution of anaerobic metabolism to reactive hyperemia in skeletal muscle
Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2643 - H2653.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. M. Quayle, M. R. Turner, H. E. Burrell, and T. Kamishima
Effects of hypoxia, anoxia, and metabolic inhibitors on KATP channels in rat femoral artery myocytes
Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H71 - H80.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C. J Ray and J. M Marshall
Measurement of nitric oxide release evoked by systemic hypoxia and adenosine from rat skeletal muscle in vivo
J. Physiol., November 1, 2005; 568(3): 967 - 978.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
G. E. Foster, D. C. McKenzie, W. K. Milsom, and A. W. Sheel
Effects of two protocols of intermittent hypoxia on human ventilatory, cardiovascular and cerebral responses to hypoxia
J. Physiol., September 1, 2005; 567(2): 689 - 699.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. C. Frisbee
Reduced nitric oxide bioavailability contributes to skeletal muscle microvessel rarefaction in the metabolic syndrome
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R307 - R316.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. S. Win and J. M. Marshall
Contribution of prostaglandins to the dilation that follows isometric forearm contraction in human subjects: effects of aspirin and hyperoxia
J Appl Physiol, July 1, 2005; 99(1): 45 - 52.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
I. Drenjancevic-Peric, S. A. Phillips, J. R. Falck, and J. H. Lombard
Restoration of normal vascular relaxation mechanisms in cerebral arteries by chromosomal substitution in consomic SS.13BN rats
Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H188 - H195.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Wang, R. J. Roman, J. R. Falck, L. de la Cruz, and J. H. Lombard
Effects of high-salt diet on CYP450-4A {omega}-hydroxylase expression and active tone in mesenteric resistance arteries
Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1557 - H1565.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. C. Frisbee
Enhanced arteriolar {alpha}-adrenergic constriction impairs dilator responses and skeletal muscle perfusion in obese Zucker rats
J Appl Physiol, August 1, 2004; 97(2): 764 - 772.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. A. Phillips, I. Drenjancevic-Peric, J. C. Frisbee, and J. H. Lombard
Chronic AT1 receptor blockade alters mechanisms mediating responses to hypoxia in rat skeletal muscle resistance arteries
Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H545 - H552.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. C. Frisbee
Impaired skeletal muscle perfusion in obese Zucker rats
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2003; 285(5): R1124 - R1134.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Scholz
Prostaglandins
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2003; 285(3): R512 - R514.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Earley, A. Pastuszyn, and B. R. Walker
Cytochrome P-450 epoxygenase products contribute to attenuated vasoconstriction after chronic hypoxia
Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H127 - H136.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Earley and B. R. Walker
Increased nitric oxide production following chronic hypoxia contributes to attenuated systemic vasoconstriction
Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1655 - H1661.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online