AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 283: R553-R560, 2002. First published April 11, 2002; doi:10.1152/ajpregu.00544.2001
0363-6119/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/3/R553    most recent
00544.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (24)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhou, M.
Right arrow Articles by Wang, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhou, M.
Right arrow Articles by Wang, P.
Vol. 283, Issue 3, R553-R560, September 2002

Adrenomedullin binding protein-1 modulates vascular responsiveness to adrenomedullin in late sepsis

Mian Zhou, Zheng F. Ba, Irshad H. Chaudry, and Ping Wang

Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294

Adrenomedullin (AM), a potent vasodilatory peptide, plays an important role in initiating the hyperdynamic response during the early stage of sepsis. Moreover, the reduced vascular responsiveness to AM appears to be responsible for the transition from the early, hyperdynamic to the late, hypodynamic phase of sepsis. Although the novel specific AM binding protein-1 (AMBP-1) enhances AM-mediated action in a cultured cell line, it remains to be determined whether AMBP-1 plays any role in modulating vascular responsiveness to AM during sepsis. To study this, adult male rats were subjected to sepsis by cecal ligation and puncture (CLP). The thoracic aorta was harvested for determination of AM-induced vascular relaxation. Aortic levels of AMBP-1 were determined by Western blot analysis, and AM receptor gene expression in the aortic tissue was assessed by RT-PCR. The results indicate that AMBP-1 significantly enhanced AM-induced vascular relaxation in aortic rings from sham-operated animals. Although vascular responsiveness to AM decreased at 20 h after CLP (i.e., the late, hypodynamic stage of sepsis), addition of AMBP-1 in vitro restored the vascular relaxation induced by AM. Moreover, the aortic level of AMBP-1 decreased significantly at 20 h after CLP. In contrast, AM receptor gene expression was not altered under such conditions. These results, taken together, suggest that AMBP-1 plays an important role in modulating vascular responsiveness to AM, and the reduced AMBP-1 appears to be responsible for the vascular AM hyporesponsiveness observed during the hypodynamic phase of sepsis.

vasoactive peptide; complement factor H; adrenomedullin receptors; aorta; vascular relaxation; cecal ligation and puncture


This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
E. Zudaire, S. Portal-Nunez, and F. Cuttitta
The central role of adrenomedullin in host defense
J. Leukoc. Biol., August 1, 2006; 80(2): 237 - 244.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
J. G. Maresh, H. Xu, N. Jiang, C. G. Gairola, and R. V. Shohet
Tobacco smoke dysregulates endothelial vasoregulatory transcripts in vivo
Physiol Genomics, May 11, 2005; 21(3): 308 - 313.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. H. Crawford, B. K. Chacko, H. M. Pruitt, B. Piknova, N. Hogg, and R. P. Patel
Transduction of NO-bioactivity by the red blood cell in sepsis: novel mechanisms of vasodilation during acute inflammatory disease
Blood, September 1, 2004; 104(5): 1375 - 1382.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. B. Persson
The kidney and hypertension
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2003; 284(5): R1176 - R1178.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online