| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
-cell mass in fetuses of rats deprived of
protein and/or energy in last trimester of pregnancy
1 Laboratoire de Physiopathologie de la Nutrition, Centre National de la Recherche Scientifique-UMR 7059, Université Paris 7/D. DIDEROT, 75251 Paris Cedex 05; 2 Laboratoire de Biochimie, Hôpital Robert Debré, 51092 Reims Cedex; and 3 Centre de Recherche Merck-Lipha, 91385 Chilly-Mazarin Cedex, France
Fetal malnutrition is now
proposed as a risk factor of later obesity and type II diabetes. We
previously analyzed the long-term impact of reduced protein and/or
energy intake strictly limited to the last week of pregnancy in Wistar
rats. Three protocols of gestational malnutrition were used:
1) low-protein isocaloric diet (5 instead of 15%) with pair
feeding to the mothers receiving the control diet, 2)
restricted diet (50% of control diet), and 3) low
protein-restricted diet (50% of low-protein diet). Only isolated
protein restriction induced a long-term 
-cell mass decrease. In the
present study, we used the same protocols of food restriction to
analyze their short-term impact (on day 21.5 of pregnancy) on -cell mass development. A 50% -cell mass decrease was present in the three restricted groups, but low-protein diet, either associated or not to energy restriction, increased fetal -cell insulin content. Among all the parameters analyzed to further explain our results, we
found that the fetal plasma level of taurine was lowered by low-protein
diet and was the main predictor of the fetal plasma insulin level
(r = 0.63, P < 0.01). In conclusion,
rat fetuses exposed to protein and/or energy restriction during the
third part of pregnancy have a similar dramatic decrease in -cell
mass, and their ability to recover -cell mass development
retardation depends on the type of malnutrition used. Moreover, our
results support the hypothesis that taurine might play an important
role in fetal -cell mass function.
endocrine pancreas
This article has been cited by other articles:
|
|
 |
|
  M. V. Chakravarthy, Y. Zhu, M. B. Wice, T. Coleman, K. L. Pappan, C. A. Marshall, M. L. McDaniel, and C. F. Semenkovich Decreased Fetal Size Is Associated With {beta}-Cell Hyperfunction in Early Life and Failure With Age Diabetes, October 1, 2008; 57(10): 2698 - 2707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Fernandez, M. A. Martin, S. Fajardo, D. Bailbe, M. N. Gangnerau, B. Portha, F. Escriva, P. Serradas, and C. Alvarez Undernutrition does not alter the activation of beta-cell neogenesis and replication in adult rats after partial pancreatectomy Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E913 - E921. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. C. Mcmillen and J. S. Robinson Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming Physiol Rev, April 1, 2005; 85(2): 571 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Martin, E. Fernandez, A. M. Pascual-Leone, F. Escriva, and C. Alvarez Protein calorie restriction has opposite effects on glucose metabolism and insulin gene expression in fetal and adult rat endocrine pancreas Am J Physiol Endocrinol Metab, April 1, 2004; 286(4): E542 - E550. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
