AJP - Regu AJP: Heart and Circulatory Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 283: R757-R767, 2002. First published May 16, 2002; doi:10.1152/ajpregu.00098.2002
0363-6119/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/3/R757    most recent
00098.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (41)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dahly, A. J.
Right arrow Articles by Roman, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dahly, A. J.
Right arrow Articles by Roman, R. J.
Vol. 283, Issue 3, R757-R767, September 2002

Antihypertensive effects of chronic anti-TGF-beta antibody therapy in Dahl S rats

Annette J. Dahly1, Kimberly M. Hoagland1, Averia K. Flasch1, Sharda Jha2, Steven R. Ledbetter2, and Richard J. Roman1

1 Medical College of Wisconsin, Department of Physiology, Milwaukee, Wisconsin 53226; and 2 Genzyme Corporation, Framingham, Massachusetts 01701

This study examined the role of transforming growth factor-beta (TGF-beta ) in the development of hypertension and renal disease in 9-wk-old male Dahl salt-sensitive (Dahl S) rats fed an 8% NaCl diet for 3 wk. The rats received an intraperitoneal injection of a control or an anti-TGF-beta antibody (anti-TGF-beta Ab) every other day for 2 wk. Mean arterial pressure was significantly lower in Dahl S rats treated with anti-TGF-beta Ab (177 ± 3 mmHg, n = 12) than in control rats (190 ± 4 mmHg, n = 17). Anti-TGF-beta Ab therapy also reduced proteinuria from 226 ± 20 to 154 ± 16 mg/day. Renal blood flow, cortical blood flow, and creatinine clearance were not significantly different in control and treated rats; however, medullary blood flow was threefold higher in the treated rats than in the controls. Despite the reduction in proteinuria, the degree of glomerulosclerosis and renal hypertrophy was similar in control and anti-TGF-beta Ab-treated rats. Renal levels of TGF-beta 1 and -beta 2, alpha -actin, type III collagen, and fibronectin mRNA decreased in rats treated with anti-TGF-beta Ab. To examine whether an earlier intervention with anti-TGF-beta Ab would confer additional renoprotection, these studies were repeated in a group of 6-wk-old Dahl S rats. Anti-TGF-beta Ab therapy significantly reduced blood pressure, proteinuria, and the degree of glomerulosclerosis and renal medullary fibrosis in this group of rats. The results indicate that anti-TGF-beta Ab therapy reduces blood pressure, proteinuria, and the renal injury associated with hypertension.

blood pressure; proteinuria; glomerulus; kidney; renal hemodynamics; glomerulosclerosis; transforming growth factor-beta


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
P. W. Sanders
Vascular consequences of dietary salt intake
Am J Physiol Renal Physiol, August 1, 2009; 297(2): F237 - F243.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. M. Williams, A. Sarkis, K. M. Hoagland, K. Fredrich, R. P. Ryan, C. Moreno, B. Lopez, J. Lazar, F. J. Fenoy, M. Sharma, et al.
Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury
Am J Physiol Renal Physiol, December 1, 2008; 295(6): F1764 - F1777.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T.-Y. Chun, P. N. Chander, J.-W. Kim, J. H. Pratt, and C. T. Stier Jr.
Aldosterone, but not angiotensin II, increases profibrotic factors in kidney of adrenalectomized stroke-prone spontaneously hypertensive rats
Am J Physiol Endocrinol Metab, August 1, 2008; 295(2): E305 - E312.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M.-S. Zhou, I. H. Schuman, E. A. Jaimes, and L. Raij
Renoprotection by statins is linked to a decrease in renal oxidative stress, TGF-{beta}, and fibronectin with concomitant increase in nitric oxide bioavailability
Am J Physiol Renal Physiol, July 1, 2008; 295(1): F53 - F59.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. P. Cohen, G. T. Lautenslager, E. Hud, E. Shea, A. Wang, S. Chen, and C. W. Shearman
Inhibiting albumin glycation attenuates dysregulation of VEGFR-1 and collagen IV subchain production and the development of renal insufficiency
Am J Physiol Renal Physiol, February 1, 2007; 292(2): F789 - F795.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J.-W. Gu, N. Tian, M. Shparago, W. Tan, A. P. Bailey, and R. D. Manning Jr.
Renal NF-{kappa}B activation and TNF-{alpha} upregulation correlate with salt-sensitive hypertension in Dahl salt-sensitive rats
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2006; 291(6): R1817 - R1824.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
H. Matsuda, N. Fukuda, T. Ueno, Y. Tahira, H. Ayame, W. Zhang, T. Bando, H. Sugiyama, S. Saito, K. Matsumoto, et al.
Development of Gene Silencing Pyrrole-Imidazole Polyamide Targeting the TGF-beta1 Promoter for Treatment of Progressive Renal Diseases
J. Am. Soc. Nephrol., February 1, 2006; 17(2): 422 - 432.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
K. Sharma, A. Cook, M. Smith, C. Valancius, and E. W. Inscho
TGF-{beta} impairs renal autoregulation via generation of ROS
Am J Physiol Renal Physiol, May 1, 2005; 288(5): F1069 - F1077.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. J. Dahly-Vernon, M. Sharma, E. T. McCarthy, V. J. Savin, S. R. Ledbetter, and R. J. Roman
Transforming Growth Factor-{beta}, 20-HETE Interaction, and Glomerular Injury in Dahl Salt-Sensitive Rats
Hypertension, April 1, 2005; 45(4): 643 - 648.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
F. J. Teran, R. A. Johnson, B. K. Stevenson, K. J. Peyton, K. E. Jackson, S. D. Appleton, W. Durante, and F. K. Johnson
Heme oxygenase-derived carbon monoxide promotes arteriolar endothelial dysfunction and contributes to salt-induced hypertension in Dahl salt-sensitive rats
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2005; 288(3): R615 - R622.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
K. R. Spurgeon, D. L. Donohoe, and D. P. Basile
Transforming growth factor-{beta} in acute renal failure: receptor expression, effects on proliferation, cellularity, and vascularization after recovery from injury
Am J Physiol Renal Physiol, March 1, 2005; 288(3): F568 - F577.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
P. W. Sanders
Salt Intake, Endothelial Cell Signaling, and Progression of Kidney Disease
Hypertension, February 1, 2004; 43(2): 142 - 146.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
W.-Z. Ying and P. W. Sanders
The interrelationship between TGF-{beta}1 and nitric oxide is altered in salt-sensitive hypertension
Am J Physiol Renal Physiol, November 1, 2003; 285(5): F902 - F908.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
L. Gnudi, G. Viberti, L. Raij, V. Rodriguez, D. Burt, P. Cortes, B. Hartley, S. Thomas, S. Maestrini, and G. Gruden
GLUT-1 Overexpression: Link Between Hemodynamic and Metabolic Factors in Glomerular Injury?
Hypertension, July 1, 2003; 42(1): 19 - 24.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online