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Am J Physiol Regul Integr Comp Physiol 283: R918-R930, 2002; doi:10.1152/ajpregu.00170.2002
0363-6119/02 $5.00
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Vol. 283, Issue 4, R918-R930, October 2002

Gene expression analysis in burn wounds of rats

Marcus Spies1, Mohan R. K. Dasu1, Nenad Svrakic2, Olivera Nesic3, Robert E. Barrow1, J. Regino Perez-Polo3, and David N. Herndon1

1 Department of Surgery, University of Texas Medical Branch and Shriners Hospitals for Children, Galveston 77550; 3 Department of Human Genetics and Biochemistry, University of Texas Medical Branch, Galveston, Texas 77555; and 2 Department of Psychiatry, Washington University, St. Louis, Missouri 63110

The events occurring early in the burn wound trigger a sequence of local and systemic responses that influence cell and tissue survival and, consequently, wound healing and recovery. Using high-density oligonucleotide arrays we identified gene expression patterns in skin samples taken from a region of injury in the burn rat model. The associated genomic events include the differential expression of genes involved in cell survival and death, cell growth regulation, cell metabolism, inflammation, and immune response. The functional gene cluster detected and their time appearance matched the time sequence known to occur in burn wound healing.

gene expression profile; microarray; wound healing; skin; rat burn model


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