AJP - Regu AJP citation statistics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 283: R1046-R1051, 2002. First published June 27, 2002; doi:10.1152/ajpregu.00142.2002
0363-6119/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/5/R1046    most recent
00142.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Todorov, V.
Right arrow Articles by Kurtz, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Todorov, V.
Right arrow Articles by Kurtz, A.
Vol. 283, Issue 5, R1046-R1051, November 2002

Tumor necrosis factor-alpha inhibits renin gene expression

Vladimir Todorov, Markus Müller, Frank Schweda, and Armin Kurtz

Institut für Physiologie I, Universität Regensburg, D-93040 Regensburg, Germany

Renin, produced in renal juxtaglomerular (JG) cells, is a fundamental regulator of blood pressure. Accumulating evidence suggests that cytokines may directly influence renin production in the JG cells. TNF-alpha , which is one of the key mediators in immunity and inflammation, is known to participate in the control of vascular proliferation and contraction and hence in the pathogenesis of cardiovascular diseases. Thus TNF-alpha may exert its effects on the cardiovascular system through modulation of renal renin synthesis. Therefore we have tested the effect of TNF-alpha on renin transcription in As4.1 cells, which represent transformed mouse JG cells, and in native mouse JG cells in culture. Renin gene expression was also determined in mice lacking the gene for TNF-alpha (TNF-alpha knockout mice). TNF-alpha inhibited renin gene expression via an inhibition of the transcriptional activity, targeting the proximal 4.1 kb of the renin promoter in As4.1 cells. TNF-alpha also attenuated forskolin-stimulated renin gene expression in primary cultures of mouse JG cells. Mice lacking the TNF-alpha gene had almost threefold higher basal renal renin mRNA abundance relative to the control strain. The general physiological regulation of renin expression by salt was not disturbed in TNF-alpha knockout mice. Our data suggest that TNF-alpha inhibits renin gene transcription at the cellular level and thus may act as a modulator of renin synthesis in (physio)pathological situations.

As4.1 cells; juxtaglomerular cells; knockout mice


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. D. Fowler, N. D. Johnson, T. A. Haroldson, J. A. Brintnall, J. E. Herrera, S. A. Katz, and D. A. Bernlohr
Regulated renin release from 3T3-L1 adipocytes
Am J Physiol Endocrinol Metab, June 1, 2009; 296(6): E1383 - E1391.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
H. Itani, X. Liu, E. H. Sarsour, P. C. Goswami, E. Born, H. L. Keen, and C. D. Sigmund
Regulation of Renin Gene Expression by Oxidative Stress
Hypertension, June 1, 2009; 53(6): 1070 - 1076.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
V. T. Todorov, M. Desch, N. Schmitt-Nilson, A. Todorova, and A. Kurtz
Peroxisome Proliferator-Activated Receptor-{gamma} Is Involved in the Control of Renin Gene Expression
Hypertension, November 1, 2007; 50(5): 939 - 944.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
R. Mrowka, A. Steege, C. Kaps, H. Herzel, B. J. Thiele, P. B. Persson, and N. Bluthgen
Dissecting the action of an evolutionary conserved non-coding region on renin promoter activity
Nucleic Acids Res., August 1, 2007; 35(15): 5120 - 5129.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
H. I. Abdullah, P. L. Pedraza, S. Hao, K. D. Rodland, J. C. McGiff, and N. R. Ferreri
NFAT regulates calcium-sensing receptor-mediated TNF production
Am J Physiol Renal Physiol, May 1, 2006; 290(5): F1110 - F1117.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
L. Pan, Y. Wang, C. A. Jones, S. T. Glenn, H. Baumann, and K. W. Gross
Enhancer-dependent inhibition of mouse renin transcription by inflammatory cytokines
Am J Physiol Renal Physiol, January 1, 2005; 288(1): F117 - F124.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
L. Pan and K. W. Gross
Transcriptional Regulation of Renin: An Update
Hypertension, January 1, 2005; 45(1): 3 - 8.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
C. Sass, C. Blanquart, P.-E. Morange, M. Pfister, and S. Visvikis-Siest
Association Between Factor VII Polymorphisms and Blood Pressure: The Stanislas Cohort
Hypertension, November 1, 2004; 44(5): 674 - 680.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
P. B Persson
Renin: origin, secretion and synthesis
J. Physiol., November 1, 2003; 552(3): 667 - 671.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. B. Persson, A. Skalweit, R. Mrowka, and B.-J. Thiele
Control of renin synthesis
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2003; 285(3): R491 - R497.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. B. Persson
The kidney and hypertension
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2003; 284(5): R1176 - R1178.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. Mrowka, K. Steinhage, A. Patzak, and P. B. Persson
An evolutionary approach for identifying potential transcription factor binding sites: the renin gene as an example
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R1147 - R1150.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Ehmke
Mouse gene targeting in cardiovascular physiology
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R28 - R30.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online