AJP - Regu AJP: Lung Cellular and Molecular Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 283: R1198-R1209, 2002. First published August 1, 2002; doi:10.1152/ajpregu.00525.2001
0363-6119/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/5/R1198    most recent
00525.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (10)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Young, J. B.
Right arrow Articles by Boufath, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Young, J. B.
Right arrow Articles by Boufath, N.
Vol. 283, Issue 5, R1198-R1209, November 2002

Effects of rearing temperature on sympathoadrenal activity in young adult rats

James B. Young, Jeffrey Weiss, and Nadine Boufath

Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611

Animals reared at 18°C exhibit enhanced innervation of brown adipose tissue (BAT) and greater cold tolerance as adults, yet gain more weight when fed an enriched diet compared with rats reared at 30°C. To explore this paradox, sympathoadrenal activity was examined using techniques of [3H]norepinephrine ([3H]NE) turnover and urinary catecholamine excretion in male and female rats reared until 2 mo of age at 18 or 30°C. Gene expression in BAT was also analyzed for several sympathetically related proteins. Although [3H]NE turnover in heart did not differ between groups, [3H]NE turnover in BAT was consistently elevated in the 18°C-reared animals, even 2 mo after removal from the cool environment. Gene expression for uncoupling proteins 1 and 3, GLUT-4, leptin, and the alpha 1A-adrenergic receptor was more abundant in BAT and the increase in epinephrine excretion with fasting suppressed in 18°C-reared animals. These studies demonstrate that obesity consequent to exposure to 18°C in early life occurs despite tonic elevation of sympathetic input to BAT. Diminished adrenal epinephrine responsiveness to fasting may play a contributory role.

adrenal medulla; brown fat; epinephrine; norepinephrine; sympathetic nervous system


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. L. White, H. D. Braymer, D. A. York, and G. A. Bray
Effect of a high or low ambient perinatal temperature on adult obesity in Osborne-Mendel and S5B/Pl rats
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1376 - R1384.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. M. Stauss
Heart rate variability
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2003; 285(5): R927 - R931.
[Full Text] [PDF]

Home page
 JNMHome page
K. Fukuchi, Y. Ono, Y. Nakahata, Y. Okada, K. Hayashida, and Y. Ishida
Visualization of Interscapular Brown Adipose Tissue Using 99mTc-Tetrofosmin in Pediatric Patients
J. Nucl. Med., October 1, 2003; 44(10): 1582 - 1585.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. R. Vollmer and O. Skott
Rearing temperature and the sympathetic nervous system regulation of white and brown adipose tissue
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2002; 283(5): R1196 - R1197.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online